脉冲电磁场对糖尿病大鼠足底血流灌注量的影响  

Effects of Pulsed Electromagnetic Fields on Blood Perfusion of Plantar in Diabetic Rats

作　　者：苏燕平[1] 张宏[2] 雷涛[1] 季林[1] 刘娟[1] 申广浩[1] 

机构地区：[1]第四军医大学,西安710032 [2]军事医学科学院附属医院,北京100071

出　　处：《医疗卫生装备》2014年第5期15-17,共3页Chinese Medical Equipment Journal

基　　金：国家自然科学基金(31000381)

摘　　要：目的:研究脉冲电磁场对糖尿病大鼠足底血流灌注量的影响。方法:成年SD大鼠随机分为3组(8只/组):正常组(正常成年非糖尿病大鼠)、模型组(糖尿病大鼠,不施加脉冲电磁场照射)以及实验组(糖尿病大鼠,施加脉冲电磁场辐照8 h/d,6周),以足底血流灌注量为检测指标对各组糖尿病大鼠的微循环进行评估。结果:经过6周的脉冲电磁场照射,发现脉冲电磁场能够显著抑制糖尿病引起的大鼠足底血流灌注量的降低。结论:脉冲电磁场照射能够缓解糖尿病导致的大鼠足底血流灌注量的下降,并且脉冲电磁场对相关疾病导致的微循环障碍可能有积极的治疗作用,但其确切机理还有待更多的实验来加以研究证实。Objective To investigate the effects of pulsed electromagnetic fields （PEMFs） on blood perfusion of foot in diabetic rats.Methods Adult male Sprague-Dawley rats were randomly divided into three groups （eight in each group）：Normal （the non-diabetic control group）,Experiment （diabetes mellitus with PEMFs exposure group which were subjected to daily 8-h PEMFs exposure for 6 weeks） and Model （diabetes mellitus with sham PEMFs exposure group）.The blood perfusions of plantar in all groups were investigated by using Laser Doppler Flowmetry.Results After 6-week experimental exposure,it＇s found that PEMFs stimulation attenuated the decrement of blood perfusion of plantar observed in diabetic rats.Conclusion The current study demonstrates that exposure with PEMFs might prevent the decrement of blood perfusion of plantar observed in diabetic rats.It is suggested that PEMFs would play a positive role in treatment of microcirculation disturbance induced by relevant disease.However,its specific mechanism needs to be elucidated by more studies.

关 键 词：脉冲电磁场 糖尿病 血流灌注 

分 类 号：R587.1[医药卫生—内分泌]