多发性骨髓瘤免疫球蛋白M蛋白测定的结果分析  

Results analysis of IgM protein detection of multiple myeloma

作　　者：蔡惠兴[1] 苏荣[1] 黄慧萍[1] 钟敏仙 陈胜男[1] 谢湘媚[1] 卓雪芽[1] 

机构地区：[1]佛山市中医院检验科,广东佛山528000

出　　处：《现代医药卫生》2014年第10期1441-1442,1445,共3页Journal of Modern Medicine & Health

基　　金：2014年广东省佛山市卫生局医学科研课题(2014127)

摘　　要：目的对63例多发性骨髓瘤(MM)患者的血清免疫固定电泳及血清免疫球蛋白M蛋白的测定结果进行回顾性分析,探讨M蛋白检测在MM诊断中的应用。方法对63例[年龄大于或等于50岁居多(55例),50岁以下较少(8例),男性略多于女性(41∶22)]确诊为MM的患者进行免疫固定电泳、血清蛋白电泳和免疫球蛋白定量测定,并对结果进行分析比较。结果 IgG类患者所占比例最高(68.3%,43/63),游离轻链型MM最低(9.5%,6/63);无论是κ型还是λ型M蛋白,κ/λ值均显著异常。各种免疫学指标检测M蛋白阳性率,血清κ/λ最高(84.1%,53/63),血清免疫球蛋白定量最低(39.7%,25/63)。结论血清免疫球蛋白M蛋白分类及分型可为临床MM的诊断和治疗提供重要依据。Objective To retrospectively analyze the detection results of serum immunofixation electrophoresis（IFE） and serum immunoglobulin M of 63 patients with multiple myeloma（MM）,and investigate the application of M protein in the diagnosis of MM. Methods A total of 63 patients diagnosed with MM,including 50 cases with the age of 55 years or older and 8 cases with the age less than 50 years and the proportion of male to female was 41 ∶22,were selected to conduct IFE,serum protein electrophoresis and quantitative determination of immunoglobulin. The results were analyzed and compared. Results The patients with IgG had the highest proportion accounting for 68.3%（43/63）,and the free light chain MM was the lowest accounting for 9.5%（6/63）. Whatever κ-type M protein or λ-type M protein,the ratio of κ/λ was significantly abnormal. The positive rate of M protein was highest by serum κ/λ accounting for 84.1%（53/63）,while lowest by serum immunoglobulin quantitative minimum accounting for 39.7%（25/63）. Conclusion Classifications and types of M protein provide valuable basis for the diagnosis and treatment of MM clinically.

关 键 词：多发性骨髓瘤 免疫球蛋白类 分析 免疫球蛋白A 分析 免疫球蛋白G 分析 免疫球蛋白M 分析 免疫电泳 血蛋白电泳 

分 类 号：R563.1[医药卫生—呼吸系统]