子午沙鼠子鼠肾脏肾单位的发育  

The Development of Nephron in Kidney of Fetal Meriones meridianus

作　　者：张春燕[1] 侯天德[2] 程昉[2] 桑秋[2] 

机构地区：[1]河西学院农业与生物技术学院,甘肃张掖734000 [2]西北师范大学生命科学学院,兰州730070

出　　处：《四川动物》2014年第3期403-408,共6页Sichuan Journal of Zoology

基　　金：甘肃省科技计划资助项目(No.1304FKCG103);甘肃省教育厅研究生导师科研项目(No.0801-06)

摘　　要：目的探讨子午沙鼠子鼠肾单位发育过程中的形态变化。方法采用光镜技术结合显微测量技术,对子午沙鼠子鼠肾小体和肾小管进行形态观察和测量。结果与1日龄相比,7日龄子午沙鼠子鼠肾髓质与皮质的厚度比增加显著（P〈0.01）;7日龄后各日龄间无显著差异（P〉0.05）,32日龄时达4.88;肾小体的发育经过了逗号小体、S小体、Ⅲ期和Ⅳ期肾小体4个阶段,7日龄肾小体的数目增多（P〈0.05）,7～32日龄肾小体的数目基本稳定（P〉0.05）;与1日龄相比,7日龄子午沙鼠肾小体和肾小球直径显著增加（P〈0.01）,7、14、21日龄间无显著差异（P〉0.05）,与21日龄相比,32日龄显著增加（P〈0.01）;14日龄前,子午沙鼠子鼠各种肾小管直径逐步增加（P〉0.05）,14～32日龄显著增加（P〈0.01）。结论 1日龄就有少量的Ⅲ期和Ⅳ期肾小体。7日龄肾小体数目达高峰。肾小体和肾小球直径7日龄达高峰,7～21日龄基本稳定,32日龄再次增加,可能与子午沙鼠子鼠肾小球滤过原尿功能增强以适应干旱的环境有关。14～32日龄肾小管直径增加显著,肾小体与肾小管功能进一步完善。皮质中长袢型髓旁肾单位和中间肾单位比短袢型浅表肾单位多;肾皮质肾小管断面中近曲小管数量较远曲小管的多;子午沙鼠子鼠肾髓质与皮质的厚度比较大,髓袢较长,具有较强的浓缩尿液的能力以适应其干旱的生存环境。Objective Morphological changes are explored during the development of nephron for fetal Meriones meridianus. Methods The renal corpuscles and tubular of fetal Meriones meridianus are observed and measured by light microscopy and microscopic measurement techniques at different growth stages. Results Compared with day 1, thickness ratio of renal medulla and cortex were increased significantly （P 〈 0.01 ）, whereas no significance was observed after 7 days （P 〉 0.05 ） , and the value achieved 4.88 at 32 days. There were four stages during the development of renal corpuscles of fetal Meriones meridianus （comma-shaped bodies, S-shaped bodies and renal corpuscles of stage m and Ⅳ）. The number of renal corpuscle were increased at day 7 （ P 〈 0.05 ） , and stabilized after 7 - 32 days. Compared with day 1, the diameter of renal corpuscle and glomerulus of kidney were increased significantly （P 〈 0.01 ） , whereas no significance was observed after 7, 14, 21 days （P 〉0.05） ; Compared with day 21, the diameter increased significantly （P 〈0.01 ） after 32 days. The diameter of the various renal corpuscle gradually increased （ P 〉 0.05 ） , and the significance was observed after 14 days. Conclusions There was a small amount of Ⅲ and Ⅳ renal corpuscles in kidney of fetal Meriones meridianus at day 1. The number of renal corpuscle would achieve the maximum value after 7 days. The diameter of renal corpuscle and glomerular in the kidney of fetal Meriones meridianus reached a peak value at day 7, and remained stable from day 7 to 21, and then in- creased again after 32 days. This variation might be related to the function of original urine filtration of renal corpuscle to adapt arid environments. The diameter of renal tubular increased significantly at 14 - 32 days, the function of renal tubular and renal glomerular were further improved. In cortex, there were juxta medullary nephrons and midcortical nephrons which had longer Henle＇s loop ; The number of proximal convoluted tubu

关 键 词：子午沙鼠子鼠 肾单位 发育 

分 类 号：Q959.837[生物学—动物学]