高原鼢鼠对戊巴比妥钠的麻醉反应  

Anaesthetic Response of Eospalax baileyi to Pentobarbital Sodium

作　　者：崔雪峰[1,2] 林恭华[1] 张同作[1] 苏建平[1] 

机构地区：[1]中国科学院西北高原生物研究所,西宁810008 [2]中国科学院大学,北京100049

出　　处：《四川动物》2014年第3期445-448,共4页Sichuan Journal of Zoology

基　　金：国家自然科学基金项目(31372197;31370405)

摘　　要：为了解高原鼢鼠Eospalax baileyi对植物次生代谢物的解毒能力,比较分析了戊巴比妥钠对高原鼢鼠和高原鼠兔Ochotona curzoniae产生的麻醉时间,及连续注射戊巴比妥钠对实验室内高原鼢鼠麻醉时间的影响过程。研究显示,在野外状态下,雌、雄高原鼢鼠的麻醉时间分别为134.23 min±27.73 min和121.14 min±35.23 min,雌、雄高原鼠兔的麻醉时间分别为90.92 min±31.10 min和116.37 min±37.13 min。统计分析表明,高原鼢鼠的麻醉时间显著长于高原鼠兔(P<0.05),意味着高原鼢鼠的解毒能力弱于高原鼠兔,这可能与有毒植物在高原鼠兔食物中所占比例较大有关。在实验室条件下,雌、雄高原鼢鼠麻醉时间均有明显的波动,显示麻醉剂对高原鼢鼠的解毒能力有一定的诱导作用。此外,雌、雄高原鼢鼠之间麻醉时间的变化过程差别较大,这可能与两种性别的高原鼢鼠个体对新环境的应激行为明显不同有关。In order to investigate the detoxification ability of plateau zokor （Eospalax baileyi）, this study compared the anesthetic time of plateau zokor and plateau pika （Ochotona curzoniae） after treated by pentobarbital sodium for 14 days. The results showed that the anesthetic time of female and male zokors were 134.23 min±27.73 min and 121.14 min±35.23 min, respectively, and the anesthetic time of female and male zokors were 90.92 min ± 31.10 min and 116.37 min±37.13 min, respectively. Statistical analyses showed that the anesthetic time of the zokors were significantly longer than that of pikas. Under laboratorial condition, the anesthetic time of both sexes fluctuated among different time points （clays） , indicating that the anesthetic time of the zokors could be influenced by pentobarbital sodium treating. Moreover, the change processes of anesthetic time were significantly varied between female and male zokors, which might be due to the distinct behavior responses of female and male zokor individuals （ i. e. the trapped males were more nervous than females）.

关 键 词：高原鼢鼠 戊巴比妥钠 麻醉时间 植物次生代谢物 解毒能力 

分 类 号：Q959.837[生物学—动物学]