高血压病中医辨证分型与血清β_2-微球蛋白(β_2-MG)的相关性研究  

Study on relationships between TCM syndrome types of hypertension and serum β_2-microglobulin( β_2-MG)

作　　者：尹宝[1] 陈涛[1] 韩立民[2] 

机构地区：[1]江西中医药大学,江西南昌330004 [2]赣南医学院,江西赣州341000

出　　处：《赣南医学院学报》2014年第2期178-180,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的:探讨高血压病中医辨证分型与血清β2-微球蛋白(β2-MG)的相关性,以求为高血压病的中医辨证分型提供客观化依据,从而指导临床高血压病的中医辨证施治。方法:对121例高血压病患者进行血清β2-MG检测,并依据《中药新药临床研究指导原则》中的标准对每位患者进行中医辨证分型,用SPSS17.0软件进行统计学分析。结果:①与对照组相比,高血压病痰湿壅盛型、阴虚阳亢型和阴阳两虚型血清β2-MG均具有显著统计学意义(P<0.01),肝火亢盛型则无统计学意义(P>0.05)。②高血压病阴阳两虚型血清β2-MG与阴虚阳亢型的进一步比较具有统计学意义(P<0.05),与肝火亢盛型、痰湿壅盛型的进一步比较具有显著统计学意义(P<0.01),均值比较为:阴阳两虚型>阴虚阳亢型>痰湿壅盛型>肝火亢盛型。结论:①高血压病痰湿壅盛型、阴虚阳亢型和阴阳两虚型的血清β2-MG均伴有不同程度的升高,且具有一定相关性;肝火亢盛型的血清β2-MG则不具相关性。②阴阳两虚型的血清β2-MG在各中医证型中升高的程度最大,可以将血清β2-MG作为高血压病阴阳两虚证分型的客观指标。Objective：To explore the relationships between TCM syndrome types of hypertension andβ2-microglobulin（β2-MG）,so as to provide an objective basis for TCM syndrome types to guide the clinical treatment of hypertension. Meth-ods：Serum β2-MG detection of 121 cases of hypertension patients,and on the basis of Guidance Principle of Clinical Study on New Drugs of TCM in the standard for each patient by TCM syndrome types,was analyzed by SPSS17. 0 soft-ware. Results：①Compared with the control group,excessive damp-phlegm type,hyperactivity of yang due to yin defi-ciency type and deficiency of both yin and yang type of hypertension with serumβ2-MG were statistically significant（ P﹤0. 01）,while hyperactivity of liver-fire type of hypertension with serum β2-MG was not statistically significant（ P 〉0. 05）.②Further comparison of serumβ2-MG between deficiency of both yin and yang type and hyperactivity of yang due to yin deficiency type was statistically significant（P﹤0. 05）,while further comparison of serumβ2-MG between deficien-cy of both yin and yang type and hyperactivity of liver-fire type,excessive damp-phlegm type were statistically significant （P﹤0. 01）,and the result of mean comparison of serum β2-MG between different types was：deficiency of both yin and yang type〉hyperactivity of yang due to yin deficiency type 〉excessive damp-phlegm type 〉hyperactivity of liver-fire type. Conclusion：①Serum β2-MG in excessive damp-phlegm type,hyperactivity of yang due to yin deficiency type and deficiency of both yin and yang type of hypertension were associated with increased in different degree,and has a certain relevance,while serum β2-MG in hyperactivity of liver-fire type has no certain relevance.②Serumβ2-MG of deficiency of both yin and yang type increased largest of degree in all TCM syndrome types,and thus can be considered that serumβ2-MG can be used as an objective index of deficiency of both yin and yang type of hypertension.

关 键 词：高血压病 中医证型 Β2-微球蛋白 Β2-MG 

分 类 号：R259.441[医药卫生—中西医结合]