广西城乡成年人高尿酸血症的流行病学调查  

The epidemiology investigation of hyperuricemia about adults in urban and rural areas in Guangxi

作　　者：王明军[1] 张金荣[1] 潘玲[1] 廖蕴华[1] 

机构地区：[1]广西医科大学第一附属医院肾内科,广西南宁530021

出　　处：《暨南大学学报（自然科学与医学版）》2014年第3期305-309,共5页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：十一五国家科技支撑计划(2007BAI04B10);广西医疗卫生重点科研课题(重200845);广西自然科学基金项目(2010GXNSFA013178)

摘　　要：目的:调查广西普通成年人群高尿酸血症(HUA)的患病率和流行病学特点,探讨高尿酸血症的危险因素.方法:采用多阶段分层整群随机抽样的方法,对广西9 000名18岁以上常住居民进行横断面调查,通过问卷调查、体检及血液、尿液检查,重点为空腹血尿酸(SUA)指标及相关危险因素的检测,用SPSS 13.0统计软件进行数据处理,采用二分类Logistic回归分析高尿酸血症的相关危险因素.其中尿酸的测定采用氧化酶法,高尿酸血症定义为血尿酸≥420μmol/L.结果:数据完整的7 924调查对象中,平均年龄为(46.27±17.28)岁,男女比例为1∶1.14.HUA粗患病率13.1%,其中男女患病率分别为22.6%,4.9%.城市患病率8.5%,农村患病率16.5%.按2010年全国人口普查性别及年龄构成计算,广西普通人群高尿酸血症标化患病率为14.6%,经二分类Logistic回归分析提示,性别、年龄、肾功能下降、饮酒、工作强度、体质量指数(BMI)、高甘油三脂及高低密度脂蛋白血症为高尿酸血症的独立危险因素.结论:广西成人高尿酸血症患病率为14.6%,(经标化后,男性患者患病率高于女性,农村患病率高于城市).男性、年龄、肾功能下降、饮酒、工作强度、BMI、高甘油三脂及高低密度脂蛋白血症为本地区高尿酸血症的相关危险因素.Aim：To investigate the prevalence rate and the epidemiological features of hyperuricemia （HUA）among the adult residents in Guangxi province,and to search the risk factors of this disease. Methods：The multistage stratified cluster random samepling,including Cross-section survey,question-naire survey,physical examination,blood tests and urine tests,was implemented among 9,000 residents above 1 8 years old in Guangxi province.The surveys on and relevant risk factors were the key.All the da-ta were analysed by SPSS v1 3.0,and then the risk factors that relevant to hyperuricemia were applied to a Binary Logistic Regression analysis.Serum uric acid was determined by GOD-PAP and hyperuricemia was defined as the level of blood uric acid ≥420 μmol/L.Results：Among 7 ,924 completely surveyed subjects of 9,000,the average age was 46.27 ±1 7.28 years old,meanwhile the male/female ratio was 1∶1.4.Approximately,prevalence of HUA of those people was 1 3.1%,and that percentage was 22.6%and 4.9%in male and female respectively.The figure was 8.5%among urban residents,and 1 6.5%a-mong rural ones.The standardized prevalence of HUA of residents in Guangxi province was 1 4.6%,in consideration of the constituent ratio of gender and age which were concluded by nationwide population census in 201 0.A Binary Logistic Regression analysis indicated that gender,aging,deficiency of renal function,alcoholism,BMI,work intensity,inhigh triglyceride （TG） and high low density lipoprotein （LDL）in serum,are independent risk factors of hyperuricemia.Conclusion：The standardized prevalence rate of hyperuricemia of adult residents within Guangxi province was 1 4.6%,then male possessed a high-er prevalence than female,and so did urban residents than rural ones.Male,aging,deficiency of renal function,alcoholism,work intensity,BMI,high TG and high LDL in serum,were relevant risk factors of hyperuricemia in this province.

关 键 词：高尿酸血症 患病率 流行病学研究 危险因素 

分 类 号：R589.7[医药卫生—内分泌]