丁二酸酐与胺类化合物在碱性条件下的反应规律  

The reaction law of succinic anhydride with amines under basic condition

作　　者：杨健[1] 陈河如[1,2] 

机构地区：[1]暨南大学药学院中药及天然药物研究所广东广州510632 [2]暨南大学广东省中药药效物质基础及创新药物研究重点实验室,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2014年第3期320-324,共5页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金项目(81172982);广东省科技计划项目(2010A030100006)

摘　　要：以吡啶为溶剂，110℃加热6 h的反应条件下，芳香伯胺与丁二酸酐反应，主要生成N-芳香取代丁二酰亚胺，最高收率73.2％；相反，脂肪伯胺与丁二酸酐反应，主要产物为N-取代丁二酸单酰胺，收率72.5％～81.7％．探讨了结构-反应活性关系，并提出可能的反应机理．Byheatingat110℃for6happliedpyridineassolvent,themajorproductsofaromatic primary amines with succinic anhydride were N-substituted succinimides. The maximum yield was 73.2%;On the contrary,the main products of fatty primary amines with succinic anhydride were N-sub-stituted succinic acid mono-amides.The yields were arranged from 72.5%to 81.7%.The structure-re-activity relationship has been studied.A putative mechanism was also put forward.

关 键 词：丁二酰亚胺 丁二酸酐 环化 有机合成 

分 类 号：O629.7[理学—有机化学]