颅脑损伤急性期血清TNF-α和IL-1β含量的变化及临床意义  

CHANGES AND CLINICAL SIGNIFICANCE OF SERUM TNF- Α AND IL- 1ΒCONTENTS IN PATIENTS WITH ACUTE BRAIN INJURY

作　　者：张怀东[1] 谢扬[1] 张摇威 陈郁强 

机构地区：[1]汕头大学医学院第二附属医院,广东汕头515041

出　　处：《现代医院》2014年第5期13-14,30,共3页Modern Hospitals

基　　金：广东省科技厅计划项目(编号:2012B031800442)

摘　　要：目的探讨颅脑损伤急性期患者血清TNF-α和IL-1β含量的变化及临床意义。方法检测60例急性颅脑损伤患者和17例正常对照组的血清TNF-α和IL-1β含量的变化,分析颅脑损伤急性期创伤程度、临床预后、CT表现与血清中TNF-α和IL-1β含量之间的关系。结果重型颅脑损伤组血清中TNF-α、IL-1β含量高于轻型损伤组(p﹤0.05);预后不良组血清中TNF-α含量高于预后良好组(p﹤0.05)。结论血清TNF-α和IL-1β测定可作为颅脑损伤急性期的早期诊断、判断病情严重程度的重要指标,TNF-α还可作为颅脑损伤急性期预后评估的重要指标。Objective To investigate the changes and clinical significance of serum TNF- α and IL-1βcontents in patients with acute brain injury. Methods The Levels of serum TNF- α and IL- 1βin 60 patients with acute brain injury and 17 healthy people were detected. Analyze the relationship of the levels of the acute brain injury,clinical prognosis,CT manifest with the serum TNF- α and IL- 1β content. Results serum TNF- α and IL- 1βcontent in severe brain injury is higher than the minor injury（ p 0. 05）. serum TNF- α content in unfavourable prognosis group is higher than the favourable prognosis group（ p 0. 05）. Conclusion The levels of serum TNF- αand IL- 1βis the significant index about the earlier diagnosis and judge the pathogenetic conditions in acute brain injury. The levels of serum TNF- α is the significant index of the prognostic evaluation in acute brain injury.

关 键 词：颅脑损伤急性期 TNF-Α IL-1Β 

分 类 号：R442.2[医药卫生—诊断学]