人参皂苷Rh_4对小鼠移植性肿瘤的抑制作用  

Inhibitory Effect of Ginsenoside Rh_4 against Mice Transplanted Tumor

作　　者：曲媛[1,2] 王承潇[1,2] 崔秀明[1,2] 

机构地区：[1]昆明理工大学生命科学与技术学院 [2]昆明理工大学云南道地药材研究开发中心,昆明650500

出　　处：《天然产物研究与开发》2014年第5期782-786,共5页Natural Product Research and Development

基　　金：中央本级重大增减支项目(20603020129)

摘　　要：本文阐述了三七中人参皂苷Rh4的体内抗肿瘤作用。建立S180肉瘤和肝癌H22荷瘤小鼠动物模型,将接种后的小鼠随机分为阴性对照组、阳性对照组及人参皂苷Rh4高、中、低剂量组,采用腹腔给药和灌胃给药两种方式,观察人参皂苷Rh4对小鼠移植性肿瘤的体内抑制作用以及对动物免疫器官重量的影响。结果表明:采用腹腔注射给药和灌胃给药,人参皂苷Rh4各剂量组对S180肉瘤小鼠和肝癌H22小鼠肿瘤生长均有抑制作用。与阴性对照组比较,当人参皂苷Rh4剂量为4.5 mg/kg灌胃给药时,对肉瘤S180的抑制率为47.84%(P<0.01);当Rh4剂量为10.0 mg/kg腹腔注射给药时,对肝癌H22的抑制率为52.72%(P<0.01)。人参皂苷Rh4对荷瘤小鼠免疫器官未见明显影响。In this study, the anti-tumor effects of ginsenoside Rh4 on mice transplanted tumor were investigated. The mice with sarcoma S180 or hepatoma 1-122 were randomly divided into five groups： negative control group, positive control group, ginsenuside Rh4 high-dose group, middle-dose group and low-dose group. Ginsenoside Rh4 was peritoneal injected or intragastric administrated to mice. The implanted mouse model was used to observe the inhibitory effect of giusenuside Rh4 on the transplantation tumor＇ s growth and the immune organ＇ s weight. After peritoneal injection or intragastric administration of Rh4 in all dose groups,it can inhibit the growth of S180 or H22. Using intragastrie administration of Rh4 at the dose of 4.5 mg/kg, the tumor inhibition rate of bearing sarcoma S180 in mice were 47.84% （P 〈 0.01 ）, compared with the control group. The H22 tumor inhibitory rate were 52.72% （ P 〈 0.01 ） by peritoneal injection of Rh4 at the dose of 10.0 mg/kg. No evident changes were detected in their immune organs in the trial groups.

关 键 词：移植性肿瘤 Rh4 肉瘤S180 肝癌H22 免疫功能 

分 类 号：R962[医药卫生—药理学]