TRPV1与中药止痛作用研究进展  

Advance in studies on TRPV1 and analgesic effect of traditional Chinese medicines

作　　者：刘晓丽[1] 吕翠[1] 张文生[1] 

机构地区：[1]北京师范大学地表过程与资源生态国家重点实验室中药资源保护与利用北京市重点实验室教育部天然药物工程研究中心,北京100875

出　　处：《中国中药杂志》2014年第10期1757-1760,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2012ZX09103-201)

摘　　要：瞬时感受器电位香草酸受体l(trannsient receptor potentialvanilloid 1,TRPV1)是一种非选择性阳离子通道,主要表达在感觉神经元上,属于瞬时感受器电位(transient receptor potential,TRP)家族成员之一。该受体可被机械性刺激,化学性刺激或内源性配基等激活,介导疼痛的传递,导致机体功能损伤。中医认为疼痛的发生机制为"不通则痛",寒性收引和瘀血阻滞均能导致血脉不通而疼痛,清热解毒中药多数具有抗炎效果,温里药和活血化瘀药具有通畅血脉的作用。因此,无论从抗炎角度或通脉角度,清热解毒药、温里药和活血化瘀药均具有止痛作用。该文以TRPV1为靶点,对上述3类中药的止痛作用研究进行了综述。Transient receptor potential vanilloid l（TRPV1） is a non-selective positive ion channel that is mainly expressed in sensory neurons and a member of transient receptor potential（TRP） family.The receptor could be activated by mechanical irritation,chemical irritation or endogenous ligand to mediate pains and cause injury to body functions.Traditional Chinese medicine believes that the mechanism of pain is that ＂ stagnation leads to pain＂.Specifically,both of the contracture and tautness caused by cold and the blood stasis could result in blood impassability and pain.Most of traditional Chinese medicines for clearing heat and removing toxicity have the anti-inflammatory effect,while those for warming interior,and promoting blood circulation to remove blood stasis have the effect in smoothening blood vessels.Therefore,either with the anti-inflammatory effect or the effect in smoothening blood vessels,traditional Chinese medicines for clearing heat and removing toxicity,warming interior,and promoting blood circulation have the analgesic effect.In this paper,the authors summarize the analgesic effect of the above three traditional Chinese medicines,with TRPV1 as the target.

关 键 词：TRPV1 中药 止痛 

分 类 号：R285[医药卫生—中药学]