β肾上腺素能受体信号转导通路对心肌肥大的调节  

β-adrenergic Receptor Signaling Pathway and Myocardial Hypertrophy

作　　者：李琳[1] 郭涛[1] 

机构地区：[1]昆明医科大学第一附属医院心血管内科,云南昆明650032

出　　处：《心血管病学进展》2014年第3期339-342,共4页Advances in Cardiovascular Diseases

摘　　要：β肾上腺素能受体信号通路与心肌肥大和心力衰竭的发生密切相关。β肾上腺素能受体的长期激活可引起心功能异常、心肌肥大和心脏重塑。β肾上腺素能受体诱导的G蛋白偶联状态的改变、ERK信号通路激活、Epac和PKCε的活化等机制参与了心肌肥大的发生发展,阐明β肾上腺素能受体激活引起心肌肥大的信号转导机制,有助于更好地防治心肌肥大。β-adrenergic receptor（βAR） signaling pathway is involved in the induction of cardiac hypertrophy and heart failure. Sustained activation of cardiac βAR lead to heart dysfunction, myocardial hypertrophy and cardiac remodeling. βAR-induced cardiac hypertro-phy are mediated by G protein, activation of ERK, Epac （exchange proteins directly activated by cAMP） and PKCε signaling pathways. Understanding the signaling mechanisms that mediate the myocardial hypertrophy may lead to the better treatment for patients with cardiac hy pertrophy.

关 键 词：Β肾上腺素能受体 心肌肥大 信号转导 

分 类 号：R542.2[医药卫生—心血管疾病]