氮杂双环型化合物结构的NMR研究  

Stereochemical Characterization of Azabicyclo-Type Compounds by NMR Spectroscopy

作　　者：姜丹[1] 徐佳[2] 缪振春[1] 

机构地区：[1]军事医学科学院毒物药物研究所,北京100850 [2]北京协和医院,北京100730

出　　处：《波谱学杂志》2014年第2期253-261,共9页Chinese Journal of Magnetic Resonance

摘　　要：该文基于2-苯基-2-环戊基-2-羟基乙酸-3-甲基-3-氮杂双环(3,3,1)壬-9?-酯,对氮杂双环型化合物的立体化学结构的NMR测定方法进行了研究.结果表明,采用选择性远程DEPT与多频率位移选择激发一维(1D)NOESY相结合的方法,可有效解决该类化合物NMR谱的碳信号归属困难的问题,同时有助于构型和立体结构的测定.该方法对于准确阐明氮杂双环型化合物的化学结构和立体化学特征具有较好的指导意义.We present an NMR method for determining stereochemical structure of azabicyclo-type compounds, with 2-pheny-2-cycloamyl-2-hydroxyacetic-N-methly-3 azabiclo [3, 3, 1] nonane-9-carboxylate as the example. We showed that the carbon NMR spectra of azabicyclo-type compounds can be assigned effectively using the combination of multiple-frequency selective excitation double pulsed field gradient spin echo 1D NOESY and selective long-range DEPT, providing valuable information for conformation and stereo structure determination. The method presented is of significant value for studying the stereochemical characteristics and structures of azabicyclo-type compounds.

关 键 词：核磁共振(NMR) 氮杂双环 1D NOESY 选择性远程DEPT 立体化 

分 类 号：O482.53[理学—固体物理]