新型噻吩-2-甲醛不对称双缩二氨基硫脲衍生物的合成及其抗菌活性  

Synthesis and Antibacterial Activities of Novel Thiophene-2-formaldehyde Unsymmetrical Bisthiosemicarbazone Derivatives

作　　者：仇丽颖[1] 赵志刚[1] 李琳[1] 张丽娜[1] 

机构地区：[1]西南民族大学化学与环境保护工程学院,四川成都610041

出　　处：《合成化学》2014年第3期293-297,共5页Chinese Journal of Synthetic Chemistry

基　　金：中央高校基本科研业务费科学基金资助项目(11NZYQN05);四川省应用基础研究项目(2011JY0035)

摘　　要：1,3-二氨基硫脲与芳香醛在冰醋酸催化下经缩合反应制得一系列单缩二氨基硫脲(3a^3k);3a^3k分别与噻吩-2-甲醛进一步缩合合成了11个新型的噻吩-2-甲醛不对称双缩二氨基硫脲类衍生物(5a^5k),其结构经1H NMR,IR,ESI-MS和元素分析表征。初步抗菌活性测定结果表明:部分目标化合物对枯草芽孢杆菌具有抑菌活性;5d对金黄色葡萄球菌的IC50为4.29,优于对照药阿莫西林(IC506.4)。Eleven novel unsymmetrical bis thiosemicarbazones（5a ～ 5k） were synthesized by condensation of thiophene-2-formaldehyde with a series of thiosemicarbazones,which were obtained by the reaction of thiocarbohydrazide with substituted aromatic aldehydes using glacial acetic acid as the catalyst.The structures were characterized by 1H NMR,IR,ESI-MS and elemental analysis.Preliminary antibacterial activities test indicated that some target compounds exhibit certain inhibitory activities against Bacillus subtilis.5d exhibit better inhibitory activities than Amoxicillin against Staphylococcus aureus.

关 键 词：噻吩-2-甲醛 双缩二氨基硫脲 合成 抗菌活性 

分 类 号：O625.7[理学—有机化学]