复方乌连提取物镇痛、抗炎、止泻的药效学研究  

To Study the Analgesic,Anti-diarrhea and Anti-inflammatory Effects of Wulian Compound Extract

作　　者：李海清[1] 吕圭源[1] 陈素红[2] 

机构地区：[1]浙江中医药大学,杭州310053 [2]温州医科大学

出　　处：《浙江中医药大学学报》2014年第4期456-460,共5页Journal of Zhejiang Chinese Medical University

基　　金：国家自然科学基金(81274123);国家自然科学基金(81374003);浙江省重点实验室(2012E10002);浙江中医药大学校级创新团队~~

摘　　要：[目的]观察复方乌连提取物的镇痛、抗炎、止泻等药效学作用。[方法]分别采用热板法、醋酸扭体法、甲醛刺激观察镇痛作用,二甲苯致小鼠耳廓肿胀法、醋酸致腹腔毛细血管通透性增高法观察抗炎作用;番泻叶和蓖麻油致腹泻法观察止泻作用。[结果]复方乌连提取物能抑制由高热、醋酸以及甲醛刺激所致的小鼠疼痛;抑制二甲苯引起的小鼠耳廓肿胀和醋酸引起的小鼠腹腔毛细血管通透性增加;同时能延长番泻叶与蓖麻油引起的小鼠腹泻潜伏期,并能减少小鼠腹泻次数。[结论]复方乌连提取物具有显著的镇痛、抗炎、止泻作用。[Objecfive] To study the analgesic, anti-diarrhea and anti-inflammatory effects of Wulian compound extract. [Method] To study the analgesic effect of Wulian compound extract on mice with hot-plate test, writhing test, and formaldehyde stimulation, To study the anti-inflammatory effect of Wulian compound extract by mice ear-swollen induced by xylene and abdominal cavity capillary Permeability text.To study the anti-diarrhea effect of the Wulian compound extract with the method of diarrhea induced by castor oil and senna. [Results] Wulian compound extract can inhibit the pain caused by high fever, acetic acid and formaldehyde. Inhibit the xylene induced ear swelling of mice and increase of celiac capillary permeability induced by acetic acid. At the same time Wulian compound extract can prolong diarrhea latency induced by the senna and castor oil, reduce the frequency of diarrhea. [Conclusion]Compound Wulian extracts have significant antidiarrheal effect, anti-inflammatory, analgesic.

关 键 词：中药复方 镇痛 抗炎 止泻 

分 类 号：R282.71[医药卫生—中药学]