基于数据挖掘的国家级名老中医治疗肝病用药规律研究  

Analysis on Medication Rules of National Medical Masters for Treatment of Hepatopathy Based on Data Mining

作　　者：吴嘉瑞[1] 宋京美[1,2] 张冰[1] 张晓朦[1] 姜迪 

机构地区：[1]北京中医药大学,北京100102 [2]北京市卫生局临床药学研究所,北京100035

出　　处：《中国中医药信息杂志》2014年第6期30-33,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家科技支撑计划(2007BAI10B01);北京市自然科学基金(7112075);北京市中医药科技发展基金(JJ-2010-70);北京中医药大学科研创新团队项目(2011-cXTD-14);北京中医药大学"重点学科"开放课题(2013-ZDXKKF-19)

摘　　要：目的探讨国家级名老中医治疗肝病的用药规律。方法收集国家级名老中医治疗肝病处方,基于中医传承辅助系统软件构建数据库,采用关联规则apriori算法和复杂系统熵聚类方法,确定处方中各药物和药物组合的使用频数及药物之间的关联规则等。结果高频药物包括茵陈、茯苓、丹参、白术、柴胡等;高频药物组合包括"丹参,茯苓"、"白术,茯苓"、"丹参,茵陈"等;置信度为1的关联规则包括"大黄,虎杖→茵陈"、"大黄,郁金→茵陈"、"虎杖,栀子→茵陈"等。结论名老中医治疗肝病多用清热利湿、理气活血之品,配伍精巧合法。Objective To investigate the medication rules for the treatment of hepatopathy by national medical masters. Methods The prescriptions for hepatopathy were collected to build a database based on Traditional Chinese Medicine （TCM） inheritance assist system. After analyzed by the data mining, such as apriori algorithm and complex system entropy cluster, the frequency of single medicine and drug combinations that used in prescriptions, and the association rules among drugs were obtained. Results The most frequently used drugs were Herba Artemisiae Capillaris, Tuckahoe, Radix Salviae Miltiorrhizae, Rhizoma Atractylodis Macrocephalae, and Radix Bupleuri, et al. The most frequently used drug combinations were ＂Radix Salviae Miltiorrhizae, Tuckahoe＂, ＂Rhizoma Atractylodis Macrocephalae, Tuckahoe＂, and ＂Radix Salviae Miltiorrhizae, Herba Artemisiae Capillaris＇, et al. And when the confidence of drug association rules was 1, the drug combinations were ＂Radix et Rhizoma Rhei, Giant Knotweed→ Herba Artemisiae Capillaris＂, ＂Radix et Rhizoma Rhei, Radix curcumae→Herba Artemisiae Capillaris＇, ＂Giant Knotweed, Gardenia→Herba Artemisiae Capillaris＂ and so on. Conclusion The medicines were often with the actions of clearing heat, removing dampness, regulating qi and activating blood circulation, which were used for the treatment of hepatopathy by national medical masters.

关 键 词：肝病 名医经验 关联规则 聚类算法 

分 类 号：R2-05[医药卫生—中医学] R259.75