氯胺酮对学习记忆影响的研究进展  

Research Progress in Effect of Ketamine on Learning and Memory Function

作　　者：李晓丽[1,2] 朋立超[2] 金孝岠[1] 

机构地区：[1]皖南医学院附属弋矶山医院麻醉科,安徽芜湖241001 [2]复旦大学附属上海市第五人民医院麻醉科,上海200240

出　　处：《南昌大学学报（医学版）》2014年第3期88-91,共4页Journal of Nanchang University：Medical Sciences

摘　　要：氯胺酮是唯一具有镇痛作用的全身麻醉药,在儿科手术中应用广泛。未成年机体使用氯胺酮是否影响学习记忆功能一直是研究关注的焦点,大量研究表明,氯胺酮对学习记忆的影响可能通过NMDA、单胺类等受体起作用,但其具体机制仍不明确。本文就近年来国内外关于氯胺酮对学习记忆影响的研究予以综述。Ketamine is the only general anesthetic with analgesic effect and is widely used in pediatric surgery.The effect of ketamine on learning and memory function in minors has always been a focus.A large number of experiments have shown that ketamine can affect learning and memory through NMDA and monoamine receptors.However,the specific mechanism is still un-clear.This review summarizes the research progress in the effect of ketamine on learning and memory function in recent years.

关 键 词：氯胺酮 学习记忆 突触可塑性 综述 

分 类 号：R614[医药卫生—麻醉学]