舒张性心力衰竭动物模型的建立及超声心动图监测  

Establishment of Diastolic Heart Failure in Animal Model

作　　者：钟明[1] 张供[2] 张运[3] 张薇 王勇 马骁[5] 邢燕秋[1] 张圆圆 赵静[3] 王磌 

机构地区：[1]山东医科大学附属医院保健科,山东济南250012 [2]山东医科大学附属医院心外科,山东济南250012 [3]山东医科大学附属医院心内科,山东济南250012 [4]山东省省立医院 [5]济南市空军总医院 [6]济南市交通医院

出　　处：《中国医学影像技术》2001年第2期130-132,共3页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金资助 !(39970 2 94)

摘　　要：目的　建立舒张性心力衰竭 (DHF)兔动物模型。方法　采用腹主动脉缩窄法建立兔压力负荷性心肌肥厚动物模型 ,通过超声心动图监测和左心导管检查测定左室舒张末压和松弛时间常数 ,判断是否存在DHF。结果　DHF兔室间隔和左室后壁明显增厚 ,左室舒张末压明显升高 ,松弛时间常数明显延长。结论　提示本研究成功地建立了DHF动物模型 ;并且在动物模型建立的过程中 。Objective To establish animal model of diastolic heart failure.Methods DHF was produced in rabbits by abdominal aortic coarctation.Systolic and diastolic function was assessed by echocardiography and catheterization during left hypertrophy progression.Results The interventricular septum and left ventricular posterior wall thickness of DHF rabbits were significantly increased compared with sham operated rabbits.Myocardial relaxation was prolonged and left ventricular end diastolic pressure was significant increased in DHF rabbit in 8 weeks obtained through cardiac catheterization,despite normal left ventricular systolic function.Conclusion It is suggesting that rabbit model of DHF was established successfully.Echocardiography is a noninvasive method to access left ventricular diastolic and systolic function during animal model establishment. [

关 键 词：动物模型 舒张性心力衰竭 超声心动图 

分 类 号：R541.6[医药卫生—心血管疾病] R540.45[医药卫生—内科学]