狼疮肾炎患者的凝血功能研究——附77例分析  

Analysis on the coagulation functional biomarkers in patients with lupus nephritis:a report of of 77 cases

作　　者：张曦[1] 金欧[1] 黄红月[1] 侯成成[1] 古洁若[1] 

机构地区：[1]中山大学附属第三医院风湿免疫科,广州510630

出　　处：《新医学》2014年第5期332-334,共3页Journal of New Medicine

基　　金：中华医学会临床医学专项科研基金(12040700370)

摘　　要：目的：了解不同病理分型的狼疮肾炎（LN ）患者的凝血功能及相关临床指标差异。方法收集经肾脏活组织检查确诊的77例LN 患者，其中病理分型Ⅰ型12例、Ⅱ型12例、Ⅲ型4例、Ⅳ型38例、Ⅴ型11例，记录并比较各病理分型 LN 患者的凝血指标、SLE 疾病活动度指数（SLEDAI）及其他临床指标。结果77例LN患者中，病理分型Ⅲ～V型患者的PTA、Fbg升高者比例分别为47％、40％，明显高于Ⅰ～Ⅱ型患者的PTA、Fbg升高者比例（13％、17％），比较差异均有统计学意义（P＜0.05）。各型患者的PT、APTT、TT、SLEDAI以及除血脂外的其他临床指标比较差异均有统计学意义（P均＜0.05）。凝血指标与SLEDAI及临床指标无关（P＞0.05）。结论病理分型Ⅲ～V型的LN患者中PTA、Fbg升高者较多，该类患者可能更易出现高凝状态。Objectives To analyze the coagulation functional biomarkers and the related clinical features in biopsy-proven lupus nephritis （LN）patients. Methods Seventy-seven patients with LN were recruited,and the pathologically types were Ⅰ-Ⅴ （1 2,1 2,4,38 and 1 1 cases,respectively）. Coagulation functional biomarkers,SLEDAI and other clinical features were analyzed according to different pathological LN types. Results In 77 LN patients,the proportion of PTA and Fbg in typeⅢ-V patients were 47%and 40%, which were significantly higher than those in typeⅠ-Ⅱ （1 3%,1 7%,respectively）（P〈0.05 ）. Except the level of lipid,PT,APTT,TT,SLEDAI and other clinical indicators were statistically differen tiated in different LN types （all P〈0.01 ）. No significant correlations were found between the coagulation function,the SLEDAI and other clinical features between different LN types （all P〉0.01 ）. Conclusion The coagulation functional biomarkers （Fbg,PTA）are more frequently enhanced in LN Ⅲ-V patients. These patients seem to be more susceptible to hypercoagulative status.

关 键 词：狼疮肾炎 凝血功能 

分 类 号：R593.242[医药卫生—内科学]