3-(Diphenylphosphino)propanoic acid: An efficient ligand for the Cu-catalyzed N-arylation of imidazoles and 1H-pyrazole with aryl halides  

作　　者：Ya-Shuai Liu Yan Liu Xiao-Wei Ma Ping Liu Jian-Wei Xie Bin Dai 

机构地区：[1]School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan,Shihezi University

出　　处：《Chinese Chemical Letters》2014年第5期775-778,共4页中国化学快报（英文版）

基　　金：financial support of this work by the National Basic Research Program of China (973 Program, No. 2012CB722603);the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT1161);the National Natural Science Foundation of China (No. 21103114);the Doctor Foundation of Xinjiang Bingtuan (No. 2012BB010)

摘　　要：3-（Diphenylphosphino）propanoic acid（L2） has proved to be an efficient ligand for the copper-catalyzed C–N coupling reactions.N-arylation of imidazoles with aryl iodides catalyzed by CuCl/L2 was smoothly carried out in DMSO at 100 8C with a yield up to 98%.N-arylation of 1H-pyrazole with aryl iodides and bromides catalyzed by Cu（OAc）2/L2 in 1 4-dioxane also gave the corresponding products with yields of40%–98%.3-（Diphenylphosphino）propanoic acid（L2） has proved to be an efficient ligand for the copper-catalyzed C–N coupling reactions.N-arylation of imidazoles with aryl iodides catalyzed by CuCl/L2 was smoothly carried out in DMSO at 100 8C with a yield up to 98%.N-arylation of 1H-pyrazole with aryl iodides and bromides catalyzed by Cu（OAc）2/L2 in 1 4-dioxane also gave the corresponding products with yields of40%–98%.

关 键 词：Cu catalyzed C–N coupling N-arylation P O ligands 

分 类 号：O643.32[理学—物理化学]