One-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide under microwave-assisted conditions  

作　　者：Yu-Bo Jiang Wen-Sheng Zhang Hui-Ling Cheng Yu-Qi Liu Rui Yang 

机构地区：[1]Faculty of Science,Kunming University of Science and Technology [2]School of Science and Technology,Jiaozuo Teachers’ College

出　　处：《Chinese Chemical Letters》2014年第5期779-782,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China (No. 21262020);the Science and Technology Planning Project of Yunnan Province (No. KKSY201207140);the Natural Science Foundation of Yunnan Education Department (No. 09Y0081);the Analysis and Measurement Foundation of Kunming University of Science and Technology (No. 20130560) for their financial supports

摘　　要：A facile,one-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide has been achieved under microwave-assisted conditions.The reactions can be smoothly completed within a total 10 min through a two-step procedure,including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.A facile,one-pot synthesis of N-aryl propargylamine from aromatic boronic acid,aqueous ammonia,and propargyl bromide has been achieved under microwave-assisted conditions.The reactions can be smoothly completed within a total 10 min through a two-step procedure,including copper-catalyzed coupling of aromatic boronic acids with aqueous ammonia and following propargylation by propargyl bromide.

关 键 词：One-pot Microwave N-Aryl propargylamine Aromatic boronic acid Aqueous ammonia Propargyl bromide 

分 类 号：O621.3[理学—有机化学]