Lipase-catalyzed Knoevenagel condensation between α,β-unsaturated aldehydes and active methylene compounds  被引量:1

Lipase-catalyzed Knoevenagel condensation between α,β-unsaturated aldehydes and active methylene compounds

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作  者:Zhi Wang Chun-Yu Wang Hao-Ran Wang Hong Zhang Ya-Lun Su Teng-Fei Ji Lei Wang 

机构地区:[1]Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education,College of Life Science,Jilin University [2]State Key Laboratory of Supramolecular Structure and Materials,Jilin University [3]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College

出  处:《Chinese Chemical Letters》2014年第5期802-804,共3页中国化学快报(英文版)

基  金:the financial support from the National Natural Science Foundation of China (Nos. 21172093, 31070708, and 21072075);the Natural Science Foundation of Jilin Province of China (Nos. 201115039 and 20140101141JC);the Scientific Research Fund of Jilin University (No. 450060326007)

摘  要:A simple and efficient Knoevenagel condensation between a b-unsaturated aldehydes and active methylene compounds is reported.Notably,this condensation can be catalyzed by PPL(lipase from porcine pancreas) with satisfied yields(49%–92%).Moreover,PPL induces moderate Z/E selectivity in the Knoevenagel condensation.A simple and efficient Knoevenagel condensation between a b-unsaturated aldehydes and active methylene compounds is reported.Notably,this condensation can be catalyzed by PPL(lipase from porcine pancreas) with satisfied yields(49%–92%).Moreover,PPL induces moderate Z/E selectivity in the Knoevenagel condensation.

关 键 词:Lipase Knoevenagel condensation a b-Unsaturated aldehyde Active methylene compound 

分 类 号:O621.251[理学—有机化学]

 

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