Bioactive compounds from Selaginella involven Spring that protect PC-12 cells  

作　　者：Hong-Ping Long Fu-Shuang Li Kang-Ping Xu Zhong-Bao Yang Jing Li Jun Peng Gui-Shan Tan 

机构地区：[1]School of Pharmaceutical Sciences,Central South University [2]Xiangya Hospital of Central South University

出　　处：《Chinese Chemical Letters》2014年第5期805-808,共4页中国化学快报（英文版）

基　　金：supported by National Natural Science Foundation (No. 31370370);the Doctoral Program Foundation of Institutions of Higher Education of China (No. 20100162110057);Chinese Medicine Research Program of Hunan Province (Nos. 2009059 and 2010004)

摘　　要：Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.Two new compounds named as 3b 12 16-trihydroxy-6 8 11 13-abietatrien（1） （8R 80S）-4 40 8-trihydroxyl-3 30-dimethoxyl-90-lignanolide（2） and a new natural product 4 40-dihydroxyl-3 30 5 50-dimethoxyldiphenyl diketone（3） were isolated from the whole herbs of Selaginella involven Spring.The structures were elucidated by spectroscopic analyses including UV,IR,1D,2D NMR and MS methods.Additionally,these three compounds exhibited potent protective effect against the injury of PC-12 cells induced by hypoxia/reoxygenation.

关 键 词：Selaginella Selaginella involven Spring Abietane diterpenoid Lignans PC-12 cell 

分 类 号：TQ461[化学工程—制药化工]