Low generational polyamidoamine dendrimers to enhance the solubility of folic acid:A‘‘dendritic effect’’investigation  

作　　者：Yong Zhang Mei-Ying Xu Tie-Kun Jiang Wei-Zhe Huang Jiang-Yu Wu 

机构地区：[1]School of Material Sciences & Engineering,Wuhan Institute of Technology

出　　处：《Chinese Chemical Letters》2014年第5期815-818,共4页中国化学快报（英文版）

基　　金：supported by Wuhan Institute of Technology, Wuhan Chenguang Project (No. 200950431195);the National Natural Science Foundation of China (No. 51003081)

摘　　要：Low generational（G0–G2,G for generation） polyamidoamine（PAMAM） dendrimers were investigated as enhancers to improve the aqueous solubility of folic acid at pH 11 and pH 5.In these two cases,the solubility of folic acid increases with both the dendrimer concentration and generation.However,the solubilization mechanism is different.The electrostatic interaction between the primary amines of dendrimers and the ionized carboxylic groups of folic acid dominates the dissolution process at pH 11 while the increase of the solubility of folic acid at pH 5 is attributed to the hydrophobic encapsulation inside the dendrimer molecules.In addition,for comparison ethylenediamine was used as a small molecule control to examine the ‘‘dendritic effect＇＇ in the dendrimer-related solubilization process.Interestingly,PAMAM dendrimers exhibit,at pH 5,a significant superiority over ethylenediamine in enhancing solubility,whereas this ‘‘dendritic effect＇＇ cannot be observed under the basic condition.Low generational（G0–G2,G for generation） polyamidoamine（PAMAM） dendrimers were investigated as enhancers to improve the aqueous solubility of folic acid at pH 11 and pH 5.In these two cases,the solubility of folic acid increases with both the dendrimer concentration and generation.However,the solubilization mechanism is different.The electrostatic interaction between the primary amines of dendrimers and the ionized carboxylic groups of folic acid dominates the dissolution process at pH 11 while the increase of the solubility of folic acid at pH 5 is attributed to the hydrophobic encapsulation inside the dendrimer molecules.In addition,for comparison ethylenediamine was used as a small molecule control to examine the ‘‘dendritic effect＇＇ in the dendrimer-related solubilization process.Interestingly,PAMAM dendrimers exhibit,at pH 5,a significant superiority over ethylenediamine in enhancing solubility,whereas this ‘‘dendritic effect＇＇ cannot be observed under the basic condition.

关 键 词：Polyamidoamine Dendrimer Folic acid Electrostatic interaction Hydrophobic encapsulation 

分 类 号：TQ466.2[化学工程—制药化工]