Ⅰ型牛胶原蛋白生物膜对鸡趾屈肌腱损伤术后生物力学的影响  

Biomechanical Effect of Type Ⅰ Bovine Collagen Membrane on Toe Flexor Tendon Injury of Chicken

作　　者：查朱青[1] 程春生[1] 李刚[1] 单海民[1] 赵治伟[1] 宋冠鹏[1] 马文龙[1] 

机构地区：[1]河南省洛阳正骨医院,洛阳471002

出　　处：《世界中医药》2014年第5期619-622,626,共5页World Chinese Medicine

基　　金：2011河南省属科研单位社会公益项目专项基金课题:肌腱韧带防粘连膜预防肌腱损伤术后粘连的实验及临床研究

摘　　要：目的:从生物力学角度探讨Ⅰ型牛胶原蛋白生物膜预防肌腱粘连作用。方法:三黄鸡,3月龄,60只,雌雄各半,体重1.5～2.0 kg,以右足第3趾屈趾深肌腱断裂1/2吻合模型,随机分为假手术组、对照组和Ⅰ型牛胶原蛋白生物膜组,再根据取材时间分为2周组、4周组、6周组、8周组4个亚组,术后2、4、6、8周对吻合端周围粘连程度观察和对包括患侧及健侧第3趾关节屈曲角度、肌腱滑动距离、肌腱最大抗断裂负荷的生物力学检测。结果:Ⅰ型牛胶原蛋白生物膜在术后2、4、6、8周,与假手术组及对照组比较,粘连程度评分明显优于假手术组及对照组(P<0.05);生物力学指标测定显示,关节屈曲角度、肌腱滑动距离、肌腱最大抗断裂负荷各项指标,实验组均优于对照组(P<0.05)。结论:Ⅰ型牛胶原蛋白生物膜可以减少粘连,提高肌腱生物力学指标,具有一定的预防粘连的作用,是一种有效的预防肌腱粘连的新型生物性材料。Objective：To explore the preventive effect of type Ⅰbovine collagen membrane on tendon adhesion from the prospective of biomechanics.Methods：Sixty chickens at the age of 3 months, half male and half female, weighing 1.5 to 2.0 kg, were made into models with 1/2 deep tendon rupture on the third toe of the right foot .They were randomly divided into sham group , control group and type Ⅰbovine collagen membrane group .Then four subgroups were divided according to time , including 2 w group, 4 w group, 6 w group, 8 w group.The degree of anastomosis adhesion , the toe joint angle, sliding tendons buckling distance , and tendon rupture of the biggest load were detected .Results：Two, four, six, and eight weeks after the surgery , type Ⅰ bovine collagen membrane group had better results in adhesion score compared with control group （P〈0.05）;the degree of anastomosis adhesion , the toe joint angle, sliding tendons buckling distance , and tendon rupture of the biggest load were better in the treatment groups （P〈0.05）.Conclusion：TypeⅠbovine collagen membrane can reduce adhesion , improve the tendon biomechanics index , and has a certain preventive adhesion effect , which is a kind of new biological material to effectively prevent tendon adhesion .

关 键 词：Ⅰ型牛胶原蛋白生物膜 肌腱粘连 生物力学 

分 类 号：R686.1[医药卫生—骨科学]