细胞因子在2型糖尿病患者医院感染时的变化分析  

Changes of cytokines in type 2 diabetes patients with hospital infections and its clinical treatment

作　　者：寿岚[1] 张秋玲[1] 朱梦飞[1] 娄国强[1] 

机构地区：[1]杭州师范大学附属医院内分泌科,浙江杭州310015

出　　处：《中华医院感染学杂志》2014年第11期2732-2734,共3页Chinese Journal of Nosocomiology

基　　金：杭州市卫生局基金资助项目(2011Z006)

摘　　要：目的探讨细胞因子在2型糖尿病患者医院感染时的变化及治疗方法,以期为提高临床治疗水平提供参考。方法回顾性分析2010年2月-2013年2月收治的105例2型糖尿病患者临床资料,对其中发生医院感染的34例患者作为观察组,另选35例未发生医院感染的患者作为对照组,观察其在糖化血红蛋白(HbAlc)、空腹血糖(FPG)、餐后2h血糖(2hPG)及细胞因子的变化,并采用积极的治疗措施。结果对照组患者超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-2(IL-2)、胰岛素样生长因子-1(IGF-I)、干扰素-γ(IFN-γ)、血管内皮生长因子(VEGF)指标分别为(6.9±2.8)mg/L、(217.4±17.8)、(69.5±21.6)、(96.8±15.1)、(104.4±10.5)、(103.5±13.8)×10-6 mg/L;而观察组患者分别为(19.7±8.6)mg/L、(347.6±39.7)、(104.5±27.9)、(148.3±24.5)、(158.3±19.5)、(118.4±16.3)×10-6 mg/L,两组比较差异有统计学意义(P<0.05);FPG、HbAic、2hPG水平结果两组比较,差异无统计学意义。结论结合细胞因子的变化从控制血糖水平、感染等综合措施上治疗2型糖尿病并发医院感染。OBJECTIVE To study the change of cytokines in type 2 diabetes patients with hospital infections and its clinical treatment, in order to improve the clinical type 2 diabetic patients with nosocomial infections and provide a reference level. METHODS A retrospective analysis of the clinical data from 105 patients with type 2 diabetes in hospital from Feb. 2010 to Feb. 2013 was taken. The 35 patients with hospital infection were treated as observation group, another 35 cases with non-hospital infections as the control group. The changes of glycosylated hemoglobin, fasting glucose, 2-hour postprandial blood glucose, lipids and cytokines were observed, and aggressive treatment measures were performed to these patients. RESULTS The data from control group were as follows., hs-CRP （6.9±2.8） mg/L, TNF-γ （217.4±17.8） 10^-6mg/L, IL-2 （69.5±21.6）10-6mg/L, IGF-1 （96.8±15.1） 10-6mg/L, IFN-γ （104.4±10.5） 10^-6mg/L, VEGF （103.5±13.8） 10^-6mg/L, while these data in observation group corresponding index values were （19.7±8.6） rag/L, （347.6±39.7） 10-6rag/L, （104.5± 27.9） 10-6rag/L, （148. 3±24. 5） 10^-6 mg/L, （158.3±19. 5） 10^-6mg/L, （118. 4±16. 3） 10^-6mg/L. Two groups had significant differences （P〈0. 05）. About FPG, 2 h PG, lipid levels and other situation, the two groups showed no significant difference. CONCLUSIONS Considering about the changes of cytokines, measures about controlling blood sugar levels and infection and other comprehensive treatment should be taken to cure the type 2 diabetes with hospital infections.

关 键 词：2型糖尿病 医院感染 细胞因子 临床治疗 

分 类 号：R181.32[医药卫生—流行病学]