血清Ⅳ型胶原和层粘连蛋白浓度测定在慢性肝病诊断中的临床价值  

Clinical value of type Ⅳ collagen and Laminin in diagnosis of chronic liver disease

作　　者：詹浩[1] 张永学[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院核医学科,430022

出　　处：《放射学实践》2001年第2期123-124,共2页Radiologic Practice

摘　　要：目的 :评价血清Ⅳ型胶原 (Ⅳ·C)和层粘连蛋白 (LN)浓度测定对肝纤维化诊断的价值。方法 :应用放射免疫分析法测定 83例慢性肝炎患者和 2 3例肝炎后肝硬化患者的血清LN、Ⅳ·C含量。结果 :慢性肝炎患者血清LN含量为(14 5 .1± 3 7.9) μg/l,Ⅳ·C含量为 (67.6± 2 0 ) μg/l,显著高于正常人 [LN (115 .7± 17.3 ) μg/l、Ⅳ·C (49.7± 15 ) μg/l] ;肝硬化患者血清LN (2 0 7.0± 63 .3 ) μg/l、Ⅳ·C /l(92 .9± 2 8.8) μg/l ,与慢性肝炎患者相比 ,有极显著性差异。LN和Ⅳ·C对肝硬化的敏感性分别为 82 .6%、86.9%。本文还分析了肝硬化患者LN、Ⅳ·C浓度与谷丙转氨酶 (ALT)、A/G的相关系数分别为 0 .14、0 .13、0 .14、-0 .17,均无显著意义。结论 :LN和Ⅳ·C对慢性肝病纤维化的发生。Objective:To clarify the clinical significance of type Ⅳ collagen (Ⅳ·C) and laminin (LN) in diagnosis of hepatic fibrosis.Methods:The present study determined serum content of Ⅳ·C and LN in 83 patients with chronic hepatitis and 23 patients with posthepatitic cirrhosis by radioimmunoassay.Results:Serum level of LN was (145.1±37.9)μg/l,Ⅳ·C (67.6±20)μg/l,in the patients with chronic hepatitis,significantly higher than normal people[LN (115.7±17.3)μg/l、Ⅳ·C (49.7±15)μg/l respectively];in patients with posthepatitic cirrhosis serum level of LN was (207.0±63.3μg/l)、Ⅳ·C (92.9±28.8)μg/l,statistically significant compared respectively with group chronic hepatitis.The correlative analysis showed that there was positive correlation between LN and Ⅳ·C in patients with posthepatitic cirrhosis (r=0.64).The sensitivity of LN and Ⅳ·C in hepatitic cirrhosis was 82.6% and86.9% respectively.Conclusion:There is greatly clinical significance of Ⅳ·C and LN in assessment of existance and development of hepatic fibrosis in patients with chronic liver disease.

关 键 词：Ⅳ型胶原 层粘连蛋白 肝纤维化 慢性肝病 诊断 

分 类 号：R446.1[医药卫生—诊断学]