帕利哌酮联合碳酸锂治疗对双相障碍稳定期患者认知功能的影响  

The Effects of Paliperidone Combined Lithium Carbonate on Cognitive Function of Patients with Bipolar Disorder at Stationary Phase

作　　者：吴庆锋[1] 蒋健昌[1] 苏珊娜[1] 莫金灿[1] 李晓玲[1] 苏保育[1] 

机构地区：[1]佛山市第三人民医院,广东佛山528000

出　　处：《中国伤残医学》2014年第11期22-23,共2页Chinese Journal of Trauma and Disability Medicine

基　　金：佛山市医学类科技攻关项目,201308047

摘　　要：目的：探讨帕利哌酮联合碳酸锂治疗对双相障碍稳定期患者认知功能的影响。方法：60例稳定期双相障碍I 型患者分成2组，分别是帕利哌酮缓释片联合碳酸锂治疗组30例，碳酸锂单药治疗组30例。采用修订韦氏成人记忆量表（ WMS-RC）记忆广度（ MS）、威斯康星卡片分类测验（ WCST），比较组间认知、记忆和执行功能的差异。结果：帕利哌酮联合碳酸锂治疗组在WCST卡片总数（t＝3．83，P＝0．000）、持续错误（t＝2．19， P＝0．039）、随机错误（t＝3．68，P＝0．000）、WMS-RC总分（t＝2．27， P＝0．020）、记忆商数（t＝4．10，P＝0．000）、数字广度（t＝2．11，P＝0．031）均优于碳酸锂单药组。结论：帕利哌酮联合碳酸锂治疗可能有助于缓解和改善双相障碍患者认知功能。Objective：To investigate the effects of Paliperidone combined Lithium carbonate on cognitive function of patients with bipolar disorder at stationary phase .Methods：A total of 60 bipolar I disorder patients in stable state were recruited and randomly assigned to 2 groups according to the treatment of drugs：30 patients with lithium carbonate ,30 patients with Paliperidone combined Lithium carbonate . patients were assessed separately with Wechsler Menory Scale 2 revised China （WMS-RC）,Memory span subtests （MS） of Multiple Memory assessment Scale , Wisconsin Card Sorting Test （ WCST） to evaluate cognitive function , then the differences between groups were compared.Results：There were significant differences in number of total WCST tests （t=3.83, P=0.000）,number of persisting errors（t=2.19, P=0.039）,number of random errors（t=3.68, P=0.000） , total points of WMS-RC（t=2.27, P=0.020）,MQ（t=4. 10, P=0.000）,digital span（t=2.11,P=0.031） between the groups.Conclusion：The combination therapy of Paliperidone and Lithium carbonate has better effects on cognitive function of these patients with bipolar disorder .

关 键 词：帕利哌酮 双相障碍 碳酸锂 认知功能 

分 类 号：R971[医药卫生—药品]