再负荷胺碘酮治疗复发性、持续性室性心动过速的临床疗效及安全性观察  

Amiodarone Re-Loading for the Treatment of Recurrent Sustained Ventricular Tachyarrhythmias

作　　者：贺丽霞[1] 施冰[1] 朱俊[1] 宋有城[1] 袁贤奇[1] 王国干[1] 谭慧琼[1] 杨艳敏[1] 康连鸣[1] 章晏[1] 

机构地区：[1]中国医学科学院

出　　处：《中国循环杂志》2001年第1期12-13,共2页Chinese Circulation Journal

摘　　要：目的 :评价再负荷胺碘酮治疗复发性、持续性室性心动过速的临床疗效及安全性。　　方法 :12例初次负荷量胺碘酮治疗后正在口服维持量或停药不超过 3个月的复发性、持续性室性心动过速 (VT)和(或 )心室颤动 (VF)患者 ,男 11例 ,女 1例 ,平均 6 0 .75± 4.5 8岁。分别给予静脉并口服胺碘酮 (10例 ) ,单用口服胺碘酮80 0 mg/ d(2例 )再负荷治疗。　　结果 :12例复发性持续性 VT和 (或 ) VF均得到有效控制 ,未见明显副作用。再负荷胺碘酮治疗获满意疗效所需剂量约为初次负荷剂量的 6 0 %。　　结论 :再负荷胺碘酮治疗复发性、持续性 VT有良好的临床疗效及安全性。Objective:To assess the efficacy and safety of re loading amiodarone in the treatment of recurrent sustained ventricular tachyarrhythmias. Methods:Twelve patients(11 male,1 female,mean age 60 75±4 58 years)who had orally taken maintaining dose of amiodarone or stopped taking the medicine for less than 3 months and had recurrent sustained ventricular tachyarrhythmias were treated by re loading regimen.Ten patients were given both intravenous and orally while the other two orally alone. Results:Arrythmias in all the 12 patients were well controled.Compared with the initial dose small dose of amiodarone(about 60% of the original dose)was required for the satisfied effect.No significant side effects were found in all the patients. Conclusion:Re loading amiodarone for recurrent sustained ventricular tachyarrhythmias is effective and safe.

关 键 词：室性心动过速 胺碘酮 药物疗法 治疗 疗效 

分 类 号：R541.710.5[医药卫生—心血管疾病] R972.2[医药卫生—内科学]