常规剂量甲泼尼龙琥珀酸钠治疗初发儿童肾病综合征的疗效及成本分析  

The effect and cost of conventional dose Methylprednisolone in the treatment of incipient nephrotic syndrome in children

作　　者：林荣华[1] 綦巧雯[1] 黄楚君[1] 林明祥[1] 

机构地区：[1]汕头市中心医院,515031

出　　处：《国际医药卫生导报》2014年第12期1763-1765,共3页International Medicine and Health Guidance News

摘　　要：目的观察常规剂量甲泼尼龙琥珀酸钠（甲强龙）治疗儿童初发肾病综合征的疗效、不良反应及治疗成本。方法治疗组20例初发儿童肾病综合征患者予甲强龙1．4mg／（kg·d），加入葡萄糖中静脉滴注，至尿蛋白连续3次转阴，后改强的松2mg／（kg·d）口服治疗，对照组20例初发儿童肾病综合征患者起始予强的松2mg／（kg·d），分3次口服，至尿蛋白连续3次转阴，观察两组治疗效果、副作用及治疗成本。结果治疗组水肿消退时间[（10．25±3．782）d]、尿蛋白转阴时间[（14．45±4．383）dJ明显优于对照组[（12．85±3．360）d、（18．56±4．196）d]；水钠潴留、肝脏损害和院内感染等不良反应发生率低于对照组x^2=4．329，P〈0．05，且治疗成本无明显增加[治疗组：（3419．99±684．90）元，对照组：（3502．80±376．63）元1。结论常规剂量甲泼尼龙琥珀酸钠治疗原发性肾病综合征起效快、疗效好且不良反应少，治疗成本无增加，是一种安全、有效的治疗方法。Objective To observe effect, adverse reactions and cost of conventional dose Methylprednisolone in the treatment of incipient nephrotic syndrome in children. Methods In treatment group, 20 children with incipient nephrotic syndrome were treated with Methylprednisolone [1.4 mg/（kg · d）] by intravenous drip adding in glucose; after negative proteinuria three times in a row, treated with oral prednisolone [2 mg/ （kg· d）]. In control group, 20 children with incipient nephrotic syndrome were treated with oral prednisolone [2 mg/（kg · d）]. Results The time of dropsy fadeaway and proteinuria turning to negative in treatment group were shorter than those in control group [（10.25 ± 3.782）d vs. （12.85 ± 3.360）d, （14.45 ± 4.383）d vs. （18.56 ± 4.196）d]. The incidence of water-sodium retention, liver damage and hospital infection in treatment group was lower than that in control group （x^2 = 4.329, P=0.037）. Besides, cost in treatment group did not increase [（3419.99± 684.90） in treatment group, （3502.80 ± 376.63） in control group]. Conclusion Conventional dose Methylprednisolone in the treatment of incipient nephrotic syndrome in children has fast and good effect, low adverse reaetions, without cost increased, which is a safety and effective treatment method.

关 键 词：甲泼尼龙琥珀酸钠 儿童 肾变病综合征 疗效 成本 

分 类 号：R726.9[医药卫生—儿科]