肺表面活性物质治疗糖尿病孕妇新生儿呼吸窘迫综合征的临床观察  

Clinical observation on pulmonary surfactant in treatment of neonates with respiratory distress syndrome born by pregnant women with diabetes mellitus

作　　者：邓筹芬[1] 潘健儿[1] 吴玉宇[1] 杨远娟[1] 郝妮娜[1] 江洪清[1] 

机构地区：[1]广东省江门市妇幼保健院儿科,529000

出　　处：《中国妇幼保健》2014年第17期2724-2726,共3页Maternal and Child Health Care of China

摘　　要：目的:观察外源性肺表面活性物质(PS)治疗糖尿病孕妇新生儿呼吸窘迫综合征(NRDS)的疗效。方法:将28例糖尿病孕妇NRDS分成PS组13例和非PS组15例,PS组在机械通气及常规治疗同时使用PS,非PS组仅予机械通气及常规治疗,比较两组新生儿的治疗效果。结果:使用PS治疗后,PS组新生儿OI持续下降、a/A PO2、VEI持续升高,与治疗前比较差异有统计学意义(P<0.01),同比非PS组差异有统计学意义(P<0.01);PS组机械通气、用氧和住院时间显著少于非PS组,差异有统计学意义(P<0.05)。结论:PS治疗能有效地改善糖尿病孕妇NRDS病例的肺顺应性及氧合功能,缩短机械通气、用氧及住院时间。Objective： To observe the curative effect of pulmonary surfactant （PS） in treatment of neonates with respiratory distress syndrome born by pregnant women with diabetes mellitus. Methods： Twenty - eight neonates with respiratory distress syndrome born by pregnant women with diabetes mellitus were divided into PS group （13 neonates） and non -PS group （15 neonates）, the neonates in PS group were treated with mechanical ventilation, routine treatment and PS replacement therapy; the neonates in non - PS group were treated with mechanical ventilation and routine treatment; the curative effects in the two groups were compared. Results： After treatment, OI decreased continuously, a/A PO2 and VEI increased continuously in PS group, compared with before treatment, there were statistically significant differences （ P 〈 0. 01 ）, and compared with non - PS group, there was also statistically significant differences （ P 〈 0. 01 ） ; the duration time of mechanical ventilation, oxygen therapy time and hospitalization time in PS group were statistically significantly shorter than those in non - PS group （ P 〈 0. 05 ） . Conclusion ： PS can effectively improve pulmonary compliance and oxygenation, shorten duration time of mechanical ventilation, oxygen therapy time and hospitalization time of neonates with respiratory distress syndrome born by pregnant women with diabetes mellitus.

关 键 词：肺表面活性物质 糖尿病孕妇 新生儿 呼吸窘迫综合征 

分 类 号：R722.2[医药卫生—儿科]