氧驱雾化吸入防治鼻咽癌患者放射性口腔黏膜反应的效果评价  

The preventive effectiveness of oxygen atomization inhalation on radiotherapy induced mucositis in patients with nasopharyngeal cancer

作　　者：徐娟[1] 闫荣[1] 卓培英[1] 李冉冉[1] 葛红霞[1] 鲁文芳[1] 

机构地区：[1]山东省肿瘤医院放五病区,济南市250117

出　　处：《中华护理杂志》2014年第6期667-670,共4页Chinese Journal of Nursing

摘　　要：目的探讨氧驱雾化吸入综合防治鼻咽癌患者放射治疗所致口腔黏膜反应的效果。方法将60例采用瘤床整合补量调强放射治疗的鼻咽癌放射治疗患者随机分为实验组与对照组各30例。两组患者从放射治疗开始每天给予口腔护理，保持口腔卫生，每日于放射治疗前后及进食后漱口。从放射治疗开始至放射治疗疗程结束．每日于放射治疗结束后，实验组给予氧驱雾化吸入．对照组给予超声雾化吸入，均为1次／d，20min／次。监测两组放射治疗期间口腔酸碱度和唾液流量变化：记录患者进食情况．分析口腔黏膜变化与放射治疗剂量的关系；患者放射治疗结束后，自评雾化吸入改善口干、口腔咽喉疼痛的效果。结果放射治疗至33Gy时．放射治疗结束时及放射治疗结束后1周，实验组与对照组比较，口腔黏膜反应的差异有统计学意义（P〈0．05），实验组发生Ⅲ-Ⅳ级黏膜反应患者例数明显少于对照组；放射治疗至33Gy时及放射治疗结束后1周，实验组5min唾液流量及口腔pH值明显优于对照组（P〈0．01）；实验组在改善口干、减轻口腔咽喉疼痛方面，效果优于对照组，差异有统计学意义（P〈0．01）。结论氧驱雾化吸入可用于综合防治鼻咽癌患者放射性口腔黏膜反应，并有利于减轻鼻咽癌放射治疗患者的口干、口咽疼痛等不适症状。Objective To evaluate the preventive effectiveness of oxygen atomization inhalation on radiotherapy induced mucositis in patients with nasopharyngeal cancer. Methods Sixty nasopharyngeal cancer patients with simultaneous integrated boost intensity modulated radiotherapy（IMRT） were randomly assigned to either oxygen atom- ization inhalation group or uhrasonie inhalation,once a day for 20 minutes. All patients received routine oral care. The pH value and volume of saliva,food intake,the change of mouth mucosa during radiotherapy as well as the symptoms of dry mouth and sore throat after radiotherapy were compared between the two groups. Results There were significant differences in the incidence of Ⅱ or Ⅳ mncositis,the volume and pH value of saliva and the symptoms of dry mouth and sore throat between the two groups when the total dose was 33 Gy（P〈0.05 or P〈0.01）. Conclusion Oxygen atomization inhalation can reduce radiotherapy induced mucositis and relieve the uncomfortable symptoms such as dry mouth and sore throat in patients with nasopharyngeal cancer.

关 键 词：鼻咽肿瘤 氧驱雾化吸入 放射疗法 口腔黏膜 辐射损伤 

分 类 号：R473.73[医药卫生—护理学]