芎姜超临界CO_2提取物透皮凝胶的经皮渗透研究  

Transdermal Penetration of Hydrogel Containing Xiongjiang CO_2-SFE in vitro

作　　者：钦富华[1] 董宇[2] 章建民[2] 王明军[1] 

机构地区：[1]浙江医药高等专科学校,浙江宁波315100 [2]浙江省中医药研究院,杭州310007

出　　处：《中国药房》2014年第23期2116-2118,共3页China Pharmacy

基　　金：浙江省自然科学基金资助项目(No.Y2080501);宁波市科技项目(No.2007A610078)

摘　　要：目的:研究川芎、炮姜超临界CO2提取物透皮凝胶(简称芎姜超临界CO2提取物凝胶)的经皮渗透性。方法:通过透皮扩散仪测定芎姜超临界CO2提取物凝胶经离体大鼠皮肤的渗透性,分别以藁本内酯、6-姜酚为指标成分,高效液相色谱(HPLC)法测定药物含量求算累积渗透量(Q)与稳态透皮速率(JS)。结果:芎姜超临界CO2提取物凝胶中藁本内酯和6-姜酚均能有效经皮渗透,Js分别为(47.57±3.77)、(8.29±1.47)μg/(cm2·h),14 h平均累积渗透百分数分别为(26.99±1.89)%和(14.40±1.18)%。结论:芎姜超临界CO2提取物凝胶具有良好的经皮渗透性,经皮给药有望作为芎姜超临界CO2提取物的一种新给药途径。OBJECTIVE： To study the transdermal permeation of hydrogel containing CO2-SFE of Ligusticum chuanxiong and Zingiber officinale（called Hydrogel containing Xiongjiang CO2-SFE for short）. METHODS： The transdermal permeation of Hydrogel containing Xiongiiang CO2-SFE was determined by transdermal diffusion device, with ligusti＇lide and 6-shogaol as indicators. Accumulative transdermal quantity and static percutaneous rate of drugs were determined by HPLC. RESULTS：The results showed that ligustilide and 6-shogaol could both permeate across the rat skin in vitro; static percutaneous rate of them were （47.57 ± 3.77） μg/ （cm2· h） and （8.29± 1.47） μg/（cm2·h） ; 14 h average accumulative permeation percentages were （26.99 ± 1.89） % and （14.40 ± 1.18）%, respectively. CONCLUSIONS： The results show good transdermal permeation of Hydrogel containing Xiongjiang CO2-SFE. The percutanous administration is a potential route of administration for Xiongjiang CO2-SFE.

关 键 词：芎姜复方 超临界CO2提取物 经皮给药 凝胶 

分 类 号：R283.6[医药卫生—中药学]