延边地区朝鲜族与汉族人群胰岛素抵抗对代谢综合征及其组分的影响  

Effect of insulin resistance for the risks of metabolic syndrome and its components in Korean-Chinese and Han nationality population in Yanbian area

作　　者：金乃星[1] 熊英环[2] 方今女[2] 

机构地区：[1]延边大学护理学院 [2]延边大学医学院预防医学教研部,吉林延吉133002

出　　处：《延边大学医学学报》2014年第1期39-43,共5页Journal of Medical Science Yanbian University

基　　金：国家自然科学基金项目(30860244);吉林省教育厅基金项目;项目号:2008(2)

摘　　要：[目的]探讨延边地区朝鲜族和汉族人群胰岛素抵抗(IR)对代谢综合征(MS)及其组分患病危险的影响程度.[方法]在延边地区抽取7 856名朝鲜族和汉族常住居民进行现况调查,并测定MS相关代谢指标.[结果]朝鲜族和汉族HOMA-IR水平及IR检出率间存在明显差异.MS及其组分检出率均随着HOMA-IR水平升高呈升高趋势(P<0.001),而且在IR组的检出率明显高于其他组.朝鲜族和汉族人群IR检出率随着MS异常组分数的增加呈升高趋势(P<0.001).多因素Logistic回归分析结果表明,MS及其各组分的患病危险均随着HOMA-IR水平的升高而升高(P<0.01),朝鲜族人群IR组的OR值依次为79.645(高血糖),2.431(腹型肥胖),1.525(低高密度脂蛋白胆固醇血症),1.427(高三酰甘油血症),汉族人群依次为11.743(高血糖),2.702(低高密度脂蛋白胆固醇血症),1.847(腹型肥胖),1.627(高三酰甘油血症),1.367(高血压),IR对朝鲜族和汉族人群MS患病危险分别为4.649和3.750.[结论]MS及其组分的患病危险均随着HOMA-IR水平升高而呈升高趋势;IR对不同代谢异常的患病危险及其聚集强度的影响程度有所不同,且存在民族差异.OBJECTIVE To study the effect of insulin resistance （IR） for the risks of metabolic syndrome （MS） and its components in Korean-Chinese and Han nationality population in Yanbian area. METHODS A total of 7 856 residents living in Yanbian rural area were selected to be performed the prevalence survey, and the indexes related with metabolic syndrome were measured. RESULTS The HOMA-IR and detection rates of MS had significant differences between the Korean-Chinese and Han nationality, and the detection rates of MS and its components had increasing tendency along with the increase of HOMA-IR （all P〈0. 001）, and were higher in IR group than in other groups. The detection rate of IR had increasing tendency along with the increase of abnormal component number of MS in Korean-Chinese and Han nationality population （all P〈0. 001）. Logistic regression analysis showed that the risk of MS and its all components were significantly increased along with the increase of HOMA-IR （all P〈0.01）. The value of OR in IR group was 79. 645 and11. 743 （hyperglycemia）, 2. 431 and 1. 847 （central obesity）, 1.525 and 2. 702 （low HDL-C）, and 1. 427 and 1.627 （ hypertriglyceridemia ）, and 1.367 （ HBP ） in Korean-Chinese and Hancomponents are significantly increased along with the increase of HOMA-IR, and IR seems to be different effect to the risk of different metabolic disorders and MS with the ethnic differences.

关 键 词：胰岛素抵抗 代谢综合征 朝鲜族 汉族 

分 类 号：R587[医药卫生—内分泌]