胶体二氧化硅固化银杏黄酮组分磷脂复合物的研究  

Solidifying of ginkgo flavones phospholipid complex using colloidal silica

作　　者：夏海建[1,2] 张振海[2] 孙娥[2] 陈小云[1,2] 万高星河 贾晓斌[1,2] 

机构地区：[1]南京中医药大学附属中西医结合医院,江苏南京210028 [2]江苏省中医药研究院国家中医药管理局中药释药系统重点研究室,江苏南京210028

出　　处：《中草药》2014年第8期1078-1082,共5页Chinese Traditional and Herbal Drugs

基　　金：江苏省中医药领军人才专项(2006);江苏省高等学校大学生创新训练计划项目(011042004000)

摘　　要：目的制备银杏黄酮组分磷脂复合物(GF-PC),并利用胶体二氧化硅(CS)对其进行固化。方法以CS为载体,固化GF-PC。采用差示扫描量热分析(DSC)法、X射线粉末衍射分析(XPRD)法和扫描电镜(SEM)法对所制备的磷脂复合物和固化粉末进行物相表征,并考察其体外溶出和流动性。结果 DSC和XPRD图谱表明,GF以无定形状态存在于固化粉末中。体外溶出结果表明,固化粉末能够有效促进药物的溶出。结论 CS固化GF-PC的制备工艺简单、操作方便,在提高自身流动性的同时能够显著改善其溶出性。Objective To prepare ginkgo fiavones phospholipid complex （GF-PC） and to solidify it using colloidal silica （CS）. Methods CS was used as a carrier to solidify GF-PC. The structures of the phospholipid complex and solidified powder were also characterized by differential scanning calorimetry, X-ray diffractomer, and scanning electron microscope, and dissolution in vitro and fluidity were also investigated. Results The phase analysis indicated that ginkgo flavones existed in the phospholipid complex and solidified powder as amorphous state. Dissolution in vitro showed that the solidified powder could effectively promote the drug dissolution. Conclusion The process of the solidified powder is simple and convenient. The powder prepared can significantly improve the fluidity of the GF-PC and promote the dissolution in vitro.

关 键 词：银杏黄酮组分 胶体二氧化硅 磷脂复合物 固化粉末 表征 

分 类 号：R283.6[医药卫生—中药学]