五叶山小橘化学成分的研究  

Chemical constituents from stems of Glycosmis pentaphylla

作　　者：田二丽 杨光忠[2] 梅之南[2] 陈玉[1] 

机构地区：[1]中南民族大学化学与材料科学学院,湖北武汉430074 [2]中南民族大学药学院,湖北武汉430074

出　　处：《中草药》2014年第10期1358-1362,共5页Chinese Traditional and Herbal Drugs

基　　金：国家科技支撑计划项目(2012BAI27B06);湖北省自然科学基金和创新群体项目(2013CFB450;2013CFA013)

摘　　要：目的研究五叶山小橘Glycosmis pentaphylla茎的化学成分。方法采用正、反相硅胶柱色谱及半制备高效液相色谱等方法进行分离纯化，根据理化性质及波谱数据鉴定化合物的结构。结果从五叶山小橘茎95％乙醇提取物的正丁醇部位分离得到9个化合物，分别鉴定为2-羟基苯甲酸甲酯-2-O-13-D-吠喃芹菜糖基．（1--,2）-O—β—D-吡喃葡萄糖苷（1）、肌苷（2）、4-甲氧基-8-（D-β-D-吡哺葡萄糖）-2（1加-喹啉酮（3）、threo—guaiacyl—glycerol-8-O-4’-sinapylether7-O—β—D—glucopyranoside（4）、牡荆素（5）、乙基-O-β-D—u比喃葡萄糖苷（6）、异丙基-O—β—D-吡哺葡萄糖苷（7）、苏式-愈刨木基甘油（8）和赤式-愈创木基甘油（9）。结论化合物1为新化合物，命名为五叶山小橘甲素。化合物2～4、6～9为首次从山小橘属植物中分离得到。Objective To study the chemical constituents in the stems of GIycosmis pentaphylla. Methods The constituents were isolated and purified by silica gel and preparative HPLC, and their structures were elucidated by means of physicochemical properties and spectroscopic analyses. Results Nine compounds were isolated from the n-butanol-soluble fraction of 95% ethanol extract from the stems of G pentaphylla, and identified as methyl 2-hydroxybenzoate 2-O-β-D-apiofuranosyl-（1→2）-O-β-D-glucopyranoside （1）, inosine （2）, 4-methoxy-8-（O-β-D-glucopyranosyloxy）-2（1H）-quinolinone （3）, threo-guaiacyl-glycerol-8-O-4＇-sinapyl ether 7-O-β-D- glucopyranoside （4）, vitexin （5）, ethyl-O-β-D-glucopyranoside （6）, 2-propyl-O-β-D-glucopyranoside （7）, threo-guaiacyl glycerol （8）, and erythro-guaiacyl glycerol （9）. Conclusion Compound 1 is a new phenolic glycoside named glycopentosine A, and compounds 2-4 and 6--9 are isolated from the plants of Glycosmis Correa for the first time.

关 键 词：五叶山小橘 山小橘属 五叶山小橘甲素 肌苷 牡荆素 愈创木基甘油 

分 类 号：R284.1[医药卫生—中药学]