赤芝中1个新的三萜类化合物  

One new triterpenoid from fruiting body of Ganoderma lucidum

作　　者：于璐[1,2] 姚铁[2] 王萌[2] 陈丽霞[2] 邱峰[2] 王东[1] 

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中草药》2014年第10期1363-1366,共4页Chinese Traditional and Herbal Drugs

摘　　要：目的研究赤芝Ganoderma lucidum子实体的化学成分。方法利用硅胶柱色谱、凝胶柱色谱、制备液相色谱等方法进行分离、纯化,根据化合物的理化性质和波谱数据鉴定其结构。结果从赤芝子实体80%乙醇提取物醋酸乙酯萃取部位分离得到6个化合物,分别鉴定为赤芝酸B甲酯(1)、赤芝酸K甲酯(2)、赤芝酸A甲酯(3)、赤芝酸F甲酯(4)、2,4,5-三羟基苯甲醛(5)、2,5-二羟基苯甲酸(6)。结论化合物1为新的三萜类化合物,化合物5为首次从灵芝属中分离得到,化合物6为首次从赤芝中分离得到。Objective To study the chemical constituents in the dried fruiting body of Ganoderma lucidum. Methods The constituents were separated and purified by silica gel, Sephadex LH-20 column chromatography, and preparative HPLC. The structures were identified by physicochemical properties and spectral analyses. Results Six compounds were obtained from the ethyl acetate fraction of 80% ethanol extract of G. lucidum and identified as methyl lucidente B （1）, methyl lucidente K （2）, methyl lucidente A （3）, methyl lucidente F （4）, 2, 4, 5-trihydroxybenzaldehyde （5）, and 2, 5-dihydroxybcnzoic acid （6）. Conclusion Compound 1 is a new compound, compound 6 is found from the fruiting body of G. lucidum for the first time, and compound 5 is first found from the genus Ganoderma Karst.

关 键 词：赤芝 三萜 赤芝酸B甲酯 赤芝酸K甲酯 赤芝酸A甲酯 赤芝酸F甲酯 

分 类 号：R284.1[医药卫生—中药学]