急性化脓性扁桃体炎营分证外周血T淋巴细胞亚群的变化及临床意义  

Changes in peripheral blood T lymphocyte subsets and their clinical significance among acute suppurative tonsillitis patients with nutrient aspect syndrome

作　　者：刘建新[1] 曾逸笛[1] 周小青[1] 刘旺华[1] 洪净[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医杂志》2014年第5期1-3,共3页Hunan Journal of Traditional Chinese Medicine

基　　金：湖南省教育厅科研项目(编号:08C621;10A093);湖南省高校创新平台开放基金项目(编号:101C047)

摘　　要：目的:探讨急性化脓性扁桃体炎营分证患者外周血中T淋巴细胞亚群数目及比值变化的临床意义。方法:将55例观察对象分为观察组(急性扁桃体炎营分证患儿)25例与对照组(健康体检儿童)30例。采用免疫荧光流式细胞技术检测外周血T淋巴细胞亚群CD3+、CD4+、CD8+的细胞数目及细胞数比值,并进行分析比较。结果:两组CD3+、CD4+、CD8+细胞数目比较,差异均无统计学意义(P>0.05),而CD4+/CD3+和CD4+/CD8+细胞数比值明显升高,CD8+/CD3+比值明显降低,两组比较,差异均有统计学意义(P<0.05,P<0.01)。结论:急性化脓性扁桃体炎营分证可能与T淋巴细胞CD4+/CD3+和CD4+/CD8+比值升高、CD8+/CD3+比值降低有关。Objective：To investigate the changes in peripheral blood T lymphocyte subsets （cell count and ratio） and their clinical significance among acute suppurative tonsillitis （AST）patients with nutrient aspect syndrome. Methods ： Fifty - five subjects were divided into observation group （25 AST pediatric patients with nutrient aspect syndrome） and control group （30 healthy children）. The counts of CD3 ＋ , CD4 ＋ , and CD8 ＋ T cells in periph- eral blood and their ratios were determined by immunofluorescence flow cytometry and compared between the two groups. Results ： There were no significant differences in the counts of CD3 ＋ , CD4 ＋ , and CD8 ＋ T cells between the two groups（ P 〉 0. 05 ）. Compared with the control group, the observation group showed significant increases in CD4＋/CD3＋ ratio and CD4＋/CD8＋ ratio and a significant decrease in CDS＋/CD3＋ ratio（P 〈 0.05 or P 〈 0. 01 ）. Conclusion ： AST with nutrient aspect syndrome may be related to increased CD4＋/CD3 ＋ ratio and CD4 ＋ / CD8 ＋ ratio and decreased CD8 ＋/CD3 ＋ ratio.

关 键 词：急性化脓性扁桃体炎 营分证 T淋巴细胞 CD3+ CD4+ CD8+ 

分 类 号：R276.161.8[医药卫生—中医五官科学]