Enzymatic Promiscuity： ＂Amano＂ Lipase AS-catalysed Synthesis of Naphthopyran Derivatives in Anhydrous Media  

作　　者：JIANG Ling YU Hongwei 

机构地区：[1]Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310007, P. R. China

出　　处：《Chemical Research in Chinese Universities》2014年第3期396-399,共4页高等学校化学研究（英文版）

基　　金：Supported by the Program for Zhejiang Leading Team of Science ＆ Technology Innovation, China（No.2011R50007）, the National Natural Science Foundation of China（Nos.21176215, 21176102） and the Outstanding Young Scholar Grant of Zhejiang University, China（No.R4110092）.

摘　　要：＂Amano＂ lipase AS（lipase from Aspergillus niger）, which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to prepare naphthopyran derivatives in anhydrous organic solvents in moderate to good yields.＂Amano＂ lipase AS（lipase from Aspergillus niger）, which naturally hydrolyzes triglycerides, was found promiscuously to catalyze multi-component reactions of aromatic aldehydes with malononitrile and β-naphthol to prepare naphthopyran derivatives in anhydrous organic solvents in moderate to good yields.

关 键 词：＂Amano＂ lipase AS Catalytic promiscuity Multi-component reaction Naphthopyran derivative 

分 类 号：O625.151[理学—有机化学] TQ925.6[理学—化学]