Syntheses and Biological Activities of Novel 3-Bromo-1-（3-chloropy- ridin-2-yl）-N-hydroxy-N-aryl- 1H-pyrazole-5-carboxamides  

作　　者：ZHU Hongwei WANG Baolei ZHANG Xiulan XIONG Lixia YU Shujing LI Zhengming 

机构地区：[1]State Key Laboratory of Elemento-organic Chemistry, Research Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China

出　　处：《Chemical Research in Chinese Universities》2014年第3期409-414,共6页高等学校化学研究（英文版）

基　　金：Supported by the National Basic Research Program of China（No.2010CB126106）, the National Key Technologies Research and Development Program of China（No.2011BAE06B05-3） and the National Natural Science Foundation of China （No.21372133）.

摘　　要：A series of novel 3-bromo-1-（3-chloropyridin-2-yl）-N-hydroxy-N-aryl-lH-pyrazole-5-carboxamides was synthesized by the reaction of pyrazole carbonyl chloride with each of substituted phenylhydroxyamines. The latter ones were prepared in good yields by reducing substituted nitrobenzene compounds with Zn/NH4CI reductant system in alcohol. Structures of the title compounds were determined by IR, 1H NMR, and HRMS. Their insecticidal and fungicidal activities were evaluated by larvicidal test against oriental armyworm and the mycelium growth rate method, respectively.A series of novel 3-bromo-1-（3-chloropyridin-2-yl）-N-hydroxy-N-aryl-lH-pyrazole-5-carboxamides was synthesized by the reaction of pyrazole carbonyl chloride with each of substituted phenylhydroxyamines. The latter ones were prepared in good yields by reducing substituted nitrobenzene compounds with Zn/NH4CI reductant system in alcohol. Structures of the title compounds were determined by IR, 1H NMR, and HRMS. Their insecticidal and fungicidal activities were evaluated by larvicidal test against oriental armyworm and the mycelium growth rate method, respectively.

关 键 词：N-Hydroxyl amide N-Pyridylpyrazole Insecticidal activity Fungicidal activity 

分 类 号：O626.11[理学—有机化学] S482.39[理学—化学]