γ干扰素释放试验诊断儿童隐性结核感染的临床价值  

The clinical application value of interferon gamma release assays for diagnosis of latent tuberculosis infection in children

作　　者：林隆[1] 陈园园[1] 王孙尧[1] 

机构地区：[1]杭州市红十字会医院,浙江杭州310003

出　　处：《浙江医学教育》2014年第3期54-56,共3页Zhejiang Medical Education

基　　金：浙江省医药卫生科技项目(编号:2013KYA164)

摘　　要：目的:探讨γ干扰素释放试验在儿童隐性结核感染诊断中的临床价值。方法:选取同期隐性结核感染儿童患者33例,活动性结核感染儿童患者45例及健康儿童30例,分别进行γ干扰素释放试验(IGRA)、结核菌素皮肤试验(TST)和痰涂片分析,比较不同方法的阳性率。结果:隐性结核感染组和活动性结核感染组IGRA的阳性率分别是为84.85%和86.67%,显著高于TST和痰涂片分析法(P<0.05)。结论:IGRA诊断儿童隐性结核感染的敏感性及特异性强,具有重要的临床应用价值,可作为儿童隐性结核感染诊断的重要方法之一。[ Objective] To evaluate the clinical value of interferon gamma release assays （IGRA） diagnosis of latent tuberculosis infection in early childhood. [Method] During the same period, 33 pediatric patients with latent tuberculosis infection and 45 pediatric patients with active tuberculosis infection were selected, with 30 healthy children as a control group. IGRA, tuberculin skin test （TST） and sputum smear analysis were performed. The positive rates of different methods were compared. [Result] In latent tuberculosis group, the positivity was 84.85% by IGRA, which was significantly higher than TST and sputum smear test results （ P 〈 0.05）. In active tuberculosis infection group, the positivity was 86.67 % by IGRA, which was significantly higher than TST and sputum smear test results （ P 〈 0.05）. [ Conclusion] Latent tuberculosis infection diagnosis by IGRA has high sensitivity and specificity. IGRA has important clinical value and can be used as one important way to latent tuberculosis infection diagnosis.

关 键 词：Γ干扰素释放试验 隐性结核感染 结核菌素皮肤试验 

分 类 号：R725.1[医药卫生—儿科] R725.1[医药卫生—临床医学]