髓源性抑制细胞对脓毒症小鼠的保护作用  

Protective effect of myeloid-derived suppressor cells in mice with sepsis

作　　者：胡晓光[1] 童荔[1] 刘勇军[1] 曹璐[1] 朱艳平[1] 管向东[1] 蔡常洁[1] 

机构地区：[1]中山大学附属第一医院SICU,广州市510080

出　　处：《实用医学杂志》2014年第11期1690-1692,共3页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:81071536);国家自然科学基金青年科学基金项目(编号:81201452);广东省自然科学基金项目(编号:S2012010009104;S2013010015836)

摘　　要：目的:研究髓源性抑制细胞(MDSCs)对脓毒症小鼠是否有保护作用。方法:采用盲肠结扎穿孔术(CLP)制作脓毒症小鼠模型,术后不同时间点检测MDSCs在脾脏中的变化。通过CLP术后腹腔注射MDSCs,观察脓毒症小鼠炎症因子及生存率的变化。结果:随着脓毒症的进展,MDSCs在脓毒症小鼠脾脏中不断聚集,可增加抗炎因子(IL-10)的产生,减少炎症因子(INF-γ)的释放,从而改善脓毒症的预后。结论:MDSCs可以减轻脓毒症的炎症反应,提高脓毒症小鼠的生存率,从而为治疗脓毒症提供新的思路。Objective To investigate whether myeloid-derived suppressor cells （MDSCs） have a protective effect in septic mice. Methods The model of caecal ligation and puncture （CLP） was performed to induce polymicrobial sepsis in mice. The changes of MDSCs in spleens at different times after operation were studied. In order to observe the influence of MDSCs on the inflammatory factors and survival of septic mice, MDSCs were injected into the peritoneal cavities of mice after CLP. Results MDSCs accumulated in spleens of septic mice progressively. MDSCs could increase anti-inflammatory cytokine production, decrease the level of inflammatory factors, and improve the survival rate of mice with sepsis. Conclusion MDSCs can attenuate the inflammation and improve the survival rate of mice with sepsis, suggesting that intraperitoneal injection of MDSCs may provide a new direction for the treatment of sepsis.

关 键 词：脓毒症 髓源性抑制细胞 炎症反应 

分 类 号：R459.7[医药卫生—急诊医学]