生长抑素对猪体外循环下急性期炎性细胞因子TNF-α、IL-6及IL-10的影响  

Effects of somatostatin on acute plasma levels of TNF-α,IL-6 and IL-10 undergoing cardiopulmonary bypass in pigs

作　　者：蔡开灿[1] 陈鹏[1] 吴华[1] 刘太省[1] 孙慧美[1] 

机构地区：[1]南方医科大学南方医院胸心血管外科,广州市510515

出　　处：《实用医学杂志》2014年第11期1696-1698,共3页The Journal of Practical Medicine

基　　金：广东省自然科学基金项目(编号:S2011010003919);广东省教育科研"十二五"规划研究项目(编号:2012JK274)

摘　　要：目的：探讨生长抑素（SST）对猪体外循环（CPB）急性期TNF-α、IL-6及IL-10的影响。方法：选取健康家猪24只，随机分为对照组（SSOO组）、给予SST剂量5μg／kg（SS05组）、10μg／kg（SS10组）及20μg／kg（SS20组）；各组均行体外循环阻断45min。于CPB前15min（T0）、CPB结束时（T1）、术后2h（T2）、4h（T3）及6h（T4）抽取动脉血，以检测TNF—α、IL-6及IL-10水平并比较分析。结果：各组CPB后TNF—α、IL-6、IL-10水平均较T0时显著升高（．P〈0．05）；在T1～T4时，SSIO与SS20组TNF—α及IL-6水平低于SS00组（P〈0．05）．而IL-10水平则高于SS00组（P〈0．05）。结论：CPB开始前给予-定剂量的SST能够减轻体外循环急性期炎症反应；SST应用于CPB中不影响手术安全性。Objective To investigate the effects of somatostatin （SST） on levels of IL-6, IL-8 and TNF-α during CPB in pigs. Methods Twenty four healthy pigs were randomly divided into control group （SS00） and 3 experimental groups, SS05, SS10 and SS20. All pigs were performed by CPB for cardiac arrest in 45 rain. the levels of IL-6, IL-10 and TNF-α were tested and compared. Results The TNF-α, IL-6 and IL-10 levels were higher than T0 among all groups after CPB （P 〈 0.05） ; The levels of TNF-α and IL-6 after CPB in SS10, SS20 groups were lower than SS00 group（P 〈 0.05）, and the IL-10 level was higher（P 〈 0.05）. Conclusion Infusing with a certain dose of SST before CPB could down-regulate acute inflammatory response ; SST has no impact on the operative safety.

关 键 词：体外循环 全身性炎症反应 生长抑素 

分 类 号：R654.1[医药卫生—外科学]