IgA肾病肾组织诱骗受体2表达变化与肾小管、间质损伤的相关性分析  

Relationship between decoy receptor 2 expression and renal tubulointerstitial lesions in patients with IgA nephropathy

作　　者：霍本刚[1] 戴欢子[1] 张建国[1] 杨聚荣[1] 李开龙[1] 林利容[1] 陈佳[1] 张湖海 何娅妮[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所肾内科,重庆400042

出　　处：《临床内科杂志》2014年第5期344-347,共4页Journal of Clinical Internal Medicine

摘　　要：目的 观察诱骗受体2（DcR2）在IgA肾病患者肾组织的表达及其与肾组织损伤程度的相关性.方法 选取2013年1月～ 2013年9月我院肾内科肾活检证实为IgA肾病患者39例,根据IgAN牛津病理评分肾小管萎缩/间质纤维化评分将患者分为3组,同时选取13例肾错构瘤患者作为对照组.收集各组患者人口学资料、临床数据,免疫组化法检测肾组织DcR2的表达情况,并与肾脏病理损伤评分进行相关分析.结果 DcR2在IgA肾病肾小管上皮细胞表达,其表达水平随着肾脏损伤加重而逐渐增加,与肾小球硬化、肾小管萎缩、间质纤维化呈正相关.结论 DcR2可能以调控肾小管上皮细胞凋亡导致肾间质纤维化,并在IgA肾病进展中发挥重要作用.Objective To observe the relationship between Decoy receptor 2 （DcR2）expression and renal tubulointerstitial lesions in patients with IgA nephropathy.Methods Thirty-nine IgA patients diagnosed by renal biopsy in our hospital from January to September 2013 were recruited in our study,and 13 patients with renal angiomyolipoma were recruited as controls.DcR2 expressions were detected by immunohistochemical staining in renal tissues.The relationship between DcR2 expression and histological lesions score were analyzed.Results DcR2 was only expressed in renal tubular epithelial cell,and the expression of DcR2 increased gradually with the renal morphologic changes.Correlation analysis showed that the expressions of DcR2 staining were significantly associated with glomerular sclerosis and interstitial fibrosis/tubular atrophy.Conclusion DcR2 may regulate renal tubular epithelial cell apoptosis,which may lead to interstitial fibrosis,and this may contribute to the progression of renal disease.

关 键 词：IGA肾病 细胞凋亡 肾小管上皮细胞 诱骗受体2 

分 类 号：R586[医药卫生—内分泌]