天舒滴丸对急性血瘀模型大鼠血液流变学和血栓形成的影响  

Effects of Tianshu Dropping Pill on hemorheology and thrombosis in acute blood stasis model rats

作　　者：张红[1,2,3] 曹亮[1,2,3] 李娜[1,2,3] 唐朝辉[1,2,3] 丁岗[1,2,3] 王振中[1,2,3] 萧伟[1,2,3] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001 [2]中药制药过程新技术国家重点实验室,江苏连云港222001 [3]江苏省企业院士工作站,江苏连云港222001

出　　处：《现代药物与临床》2014年第5期471-475,共5页Drugs & Clinic

基　　金：国家重大新药创制项目(2012ZX09201201-002)

摘　　要：目的研究天舒滴丸对急性血瘀模型大鼠血液流变学、血小板聚集及血栓形成的影响。方法 SD大鼠随机分为对照组、模型组、天舒胶囊(4.0 g/kg)组、天舒滴丸(1.0、2.0、4.0 g/kg)组,ig给药3 d后,采用肾上腺素配合冰浴制备大鼠急性血瘀模型,分别测定全血黏度,血浆黏度,红细胞压积,血沉,体外形成血栓的长度、湿质量、干质量,血小板聚集率等指标。结果天舒滴丸能明显降低急性血瘀模型大鼠全血和血浆黏度,明显降低血栓长度、血栓湿质量和干质量,抑制模型大鼠血小板聚集率的升高。结论天舒滴丸能够改善急性血瘀模型大鼠血液流变性,抑制血小板聚集及血栓形成。Objective To study the effects of Tianshu Dropping Pill on hemorheology, thrombosis, and platelet aggregation in acute blood stasis model rats. Methods The mice were divided into six groups such as control, model, Tianshu Capsule （4.0 g/kg）, and Tianshu Dropping Pill （1.0, 2.0, and 4.0 g/kg） groups. After ig administration for 3 d, the acute blood stasis rat model was established by sc injection of adrenaline hydrochloride and being socked in ice-water. Viscosity of blood and plasma, erythrocyte sedimentation, hematocrit, rates of platelet aggregation, and wet weight, length, and dry weight of thrombosis formed in vitro were determined. Results Tianshu Dropping Pill could not only significantly decrease the viscosity of whole blood and plasma, but also remarkably inhibit the rates of platelet aggregation and reduce the wet weight, length, and dry weight of thrombosis. Conclusion Tianshu Dropping Pill can obviously ameliorate the hemorheology and inhibit platelet aggregation and thrombosis in acute blood stasis rats.

关 键 词：天舒滴丸 偏头痛 血液流变学 血小板聚集 血栓 

分 类 号：R285.5[医药卫生—中药学]