MR氢质子波谱在多发性硬化中的初步研究  

The clinical application of ~1H – MR spectroscopy in multiple sclerosis

作　　者：袁蕾蕾[1] 

机构地区：[1]泰山医学院附属泰山医院放射科,山东泰安市271000

出　　处：《泰山医学院学报》2014年第4期257-260,共4页Journal of Taishan Medical College

摘　　要：目的探索磁共振氢质子波谱技术对颅脑多发性硬化的临床价值。方法对28例经完整资料诊断为多发性硬化患者于脑内病灶和病灶周围正常表现脑白质区(NAWM)行多体素1H-MRS检查,并选择健康志愿者25例作为对照组。结果与健康对照组相比,病变区及NAWM的NAA/Cr值均明显降低(P<0.05);强化病灶与无强化病灶NAA/Cr值相比差异无统计学意义(P>0.05),而Cho/Cr值相比差异有统计学意义(P<0.05)。无强化病灶与NAWM的NAA/Cr值相比差异有统计学意义(P<0.05),而Cho/Cr值相比差异无统计学意义(P>0.05)。结论利用1H-MRS技术可以为多发性硬化的病灶内及病灶周围表现正常的脑白质提供特征性病理改变的信息,并能与病理改变很好的联系起来,有助于我们对多发性硬化的脱髓鞘和非脱髓鞘病理改变的认识。Objective：To investigate the clinical application of 1 H-MRS in the brain multiple sclerosis（ MS）. Meth-ods：Conventional MR imaging were obtained in the 28 patients with multiple sclerosis and 25 healthy control subjects. All the subjects were examined by 1 H-MRS. Result：Compared with healthy group,there was a significant decrease in the ra-tio NAA/Cr the lesions and NAWM（P﹤0. 05）. Compared with no enhancing lesions,the ratio of NAA/Cr in NAWM was decreased（P﹤0. 05）and there was no significant difference between them in the ratio of Cho/Cr（P﹥0. 05）. Compared with no enhancing lesions,there was no significant difference in the ratio of NAA/Cr in enhancing lesions（ P﹥0. 05）,but there was greatly increased in the ratio of Cho/Cr. Conclusion：1 H-MRS offer the potential value for improved diagnosis, better understanding of the underlying mechanisms,improved disease monitoring and guidance of the therapy of MS.

关 键 词：磁共振氢质子波谱成像 多发性硬化 代谢 N-乙酰天冬氨酸 胆碱 肌酸 

分 类 号：R445.2[医药卫生—影像医学与核医学]