NF-κB的负性调控机制在肿瘤发展与治疗的研究进展  

Negative Regulation of NF-κB and Its Role in Tumor Development and Treatment

作　　者：向阳芳[1,2] 石敏 徐智[1] 

机构地区：[1]中南大学湘雅医院药学部,湖南长沙410008 [2]中南大学药学院,湖南长沙410013

出　　处：《现代生物医学进展》2014年第16期3153-3157,共5页Progress in Modern Biomedicine

基　　金：国家自然科学基金青年基金项目(81200047)

摘　　要：有观点认为肿瘤是一种慢性炎症性疾病。NF-κB作为自然免疫和炎症的重要调节因子及内源性促肿瘤因子,其激活与许多恶性肿瘤的发生和发展密切相关。本文通过对有关NF-κB与肿瘤的文献进行分析,综述了NF-κB信号通路及其负性调控因子对肿瘤的影响的研究进展,从而论证NF-κB与肿瘤的关系以及NF-κB抑制剂在临床治疗中的意义。NF-κB （nuclear factor kappa B） family transcription factors are regarded as regulators of inflammation and immunity in cancer development, and the activation of NF-κB can accelerate the pathological process of the malignant tumor. Thus, we review the relationship between NF-κB signaling pathway, especially including negative regulatory factor, and caner etiology. Furthemore, NF-κB inhibition agent in the cancer clinical treatment is discussed in the review as well.

关 键 词：NF-ΚB 负性调控 NF—κB抑制剂 肿瘤 

分 类 号：Q730.231[生物学—分子生物学] R34[医药卫生—基础医学]