中药药代动力学研究进展  

Research Progress in Pharmacokinetics Research of Traditional Chinese Medicine

作　　者：余健[1] 辛艳飞[1] 宣尧仙[1] 

机构地区：[1]浙江省医学科学院安全性评价研究中心,浙江杭州310000

出　　处：《中华中医药学刊》2014年第6期1337-1340,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家"十二五"科技重大专项(2011ZX09301-003);浙江省中医药管理局重点项目(2013ZZ003);浙江省科技计划项目(2010F10026)

摘　　要：中药制剂组分较为复杂,作用靶点较多,其药代动力学研究与仅关注单一成分或生物效应的经典药代动力学研究具有较大的差异。近年来,为了全面阐述中药吸收、分布、代谢、排泄的体内过程,推动中药现代化,中药药代动力学成为近年来兴起的中药研究新领域,研究者们在血药浓度法、生物效应法和药动/药效学模型结合法等经典药代动力学研究方法的基础上提出了中药整合药代动力学、药代标志物、指征药代动力学和中药复方谱动学新研究方法等中药药代动力学研究新方法、新思路,大大推进了中药药代动力学研究的发展。查阅通过近年来中药药代动力学相关研究的文献,并对其中新方法新思路进行总结,综述了中药药代动力学近年来的研究现况和前沿进展。Traditional Chinese medicine （TCM） is a kind of pharmaceutics with complicate content and muhiple targets. The pharmacokinetics research of TCM is significantly different from the research of classic western medicine which only focuses on single compound or effect. Recently, in order to fully understand the ADME process of TCM and make a contribution to the modernization of TCM industry, pharmacokinetics of TCM has become another new focus in the research of TCM. New methods and new thoughts such as integrated pharmacokinetics, pharmacokinetics marker,indicated pharmacokinetcs and chromatopharmacokinetics are brought up on the basis of classic research methods, such as blood concentration method,pharmacological method and PK/PD model method. In this paper, we reviewed and commented the progress about the pharmacokinetics study of TCM.

关 键 词：整合药代动力学 药代标志物 指征药代动力学 谱动学 

分 类 号：R969.1[医药卫生—药理学]