中医药治疗妊娠期肝内胆汁淤积症疗效观察  

To Study thone Effect of Intrahepatic Cholestasis of Pregnancy by Chinese Medicine

作　　者：上官雪军[1] 

机构地区：[1]浙江大学医学院附属妇产科医院产科,浙江杭州310006

出　　处：《中华中医药学刊》2014年第6期1404-1406,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省教育厅科研基金项目(G20060400)

摘　　要：目的:探讨中医药治疗妊娠期肝内胆汁淤积症临床疗效,为妊娠期肝内胆汁淤积症的患者提供更好的治疗。方法:选取医院2010年12月—2012年12月收治的妊娠期肝内胆汁淤积症患者96例进行研究,按照临床研究随机对照的原则将患者随机分为两组,对照组48例采用思美泰或熊去氧胆酸治疗,观察组48例在对照组基础上采用口服中药疏利肝胆、消热利湿,治疗2周后观察两组皮肤瘙痒、肝功生化改善情况,比较分娩后两组围生儿及产妇预后。结果:治疗2周后,观察组患者瘙痒症状明显减轻且丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血清总胆汁酸(TBA)也明显下降,与对照组相比,差异均具有统计学意义,P<0.05。观察组患者孕周延长、新生儿体重增加改善效果明显好于对照组,差异具有统计学意义,P<0.05。结论:中医药治疗妊娠期肝内胆汁淤积症效果显著,且可以提高患者的预后及围生儿质量。Objective ： To study the effect of intrahepatic cholestasis of pregnancy by chineseChinese medicine. It could for provide providing a better way to treat the intrahepatie cholestasis of pregnancy. Methods ：96 patients with intrahepatic cholestasis of pregnancy from December 2010 to December 2012 in our hospital were to be studied. They were divided into two groups bu randomly. The control group of $ 48 patients using used medicine S - adenosylmethionine, and ursodeoxycholic acid treatment, and the observation group＇s 48 cases in the control group based on the use of oral medicine added TCM medicine for Shu - li hepatobiliary, subduing liver and ehmination eliminating heat and dampness,. Awere observed after 2 weeks of treatment treatment, pruritus, and improvement of liver biochemistry, were observed and compare the two groups＇ after childbirth and maternal perinatal child prognosis were compared. Results ： After 2 weeks of treatment ,the observation group were significantly reduced itching and serum alanine aminotransferase （ALT） , aspartate aminotransferase （AST） , serum total bile acid （TBA） also were also decreased significantly, compared Compared with the control group ratio ,the differences were statistically significant, P 〈 0.05. Extend tThe observation group＇ s gestational age wereas increased gestational age, and birth weight increased to improve significantly better than those of the control group, and the difference was statistically significant, P 〈 0.05. Conclusions ： Chinese medicine treatment of intrahepatic eholestasis effect is significant, and can improve the prognosis and quality of perinatal children.

关 键 词：中药 妊娠期 肝内胆汁淤积症 临床疗效 

分 类 号：R714.12[医药卫生—妇产科学]