铅降低机体抗病毒能力的实验研究  

The experimental study on the effects of lead on the antiviral ability

作　　者：朱宝立[1] 杜晨阳[1] 陈敏[1] 

机构地区：[1]江苏省职业病防治研究所,江苏南京210028

出　　处：《中国工业医学杂志》2000年第6期329-331,共3页Chinese Journal of Industrial Medicine

摘　　要：目的　探讨铅对机体抗病毒能力的影响。方法　采用体外和体内实验研究。结果　铅显著增强人胚肺细胞对呼吸道合胞病毒的敏感性 ,降低细胞对呼吸道合胞病毒的抵抗力 ;在动物实验中 ,铅染毒组动物肺部病毒滴度显著增加 ,肺部病变明显加重 ,肺指数显著增加。结论　铅可降低机体的抗病毒能力 。Objective To study the effect of lead on the antiviral ability.Methods Experiments in vitro and in vivo were made to study the effect of lead on the antiviral ability of the organism.Result Lead could notably enhance the susceptivity of human embryo lung cell to respiratory syncytial virus,lower the resistance of the cells to the virus in the animals lung,worsen the pathological changes of lung and increase the lung index.Conclusion Lead can reduce the antiviral ability of organism and enhance the susceptivity to the virus.

关 键 词：铅 抗病毒能力 机体 实验 

分 类 号：R995[医药卫生—毒理学]