几种含吡啶双酰胺基双Schiff碱对大肠杆菌的抑菌活性研究  

Study of antibacterial activity of double Schiff base containing pyridine ring and diamide on E. coli

作　　者：蔡丽华[1] 张立侠[2] 

机构地区：[1]武汉长江工商学院工学院,湖北武汉430065 [2]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《化学研究与应用》2014年第3期436-440,共5页Chemical Research and Application

摘　　要：使用LKB 2277热活性监测器测定了大肠杆菌在几种含吡啶双酰胺基双Schiff碱作用下的生热曲线,得到了不同Schiff碱在不同浓度下大肠杆菌生长代谢的生热速率常数k、传代时间、半抑制量浓度。结果发现,含有2,4-二羟基苯甲醛双Schiff碱(Ⅱa和Ⅱg)对大肠杆菌生长代谢的抑制活性要明显大于含其他Schiff碱,而杂环Schiff碱对大肠杆菌抑菌活性顺序为吡啶>噻吩>呋喃。An LKB-2277 thermal activity monitor was used to monitor the cell metabolic activity in vitro to produce thermogenesis curves. The growth rate constants k,generation time of growth thermogenic curves t of E. coli in different Schiff base at different con-centrations and IC50 were deduced from these thermogenesis curves. Thus,Schiff base containing pyridine ring and diamide showed inhibiting action on the growth metabolism of E. coli. 2,4-dihydroxyphenyl Schiff base（ IIa and IIg ） being the better ones. And the sequence of heterocyclic Schiff base was pyridine〉thiophene〉furan.

关 键 词：双SCHIFF碱 大肠杆菌 抑制 吡啶双酰胺 

分 类 号：O627.41[理学—有机化学]